Filament turnover stabilizes contractile cytoskeletal structures

P. Guthardt Torres, K. Doubrovinski, K. Kruse

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Vital cellular processes depend on contractile stresses generated by the actin cytoskeleton. Commonly, the turnover of actin filaments in the corresponding structures is large. We introduce a mesoscopic theoretical description of motor-filament systems that accounts for filament nucleation, growth, and disassembly. To analyze the dynamic equations, we introduce an expansion of the filament densities in terms of generalized Laguerre polynomials. We find that filament turnover significantly stabilizes contractile structures against rupture. Finally, we relate the mesoscopic description to a phenomenological theory of cytoskeletal dynamics.

Original languageEnglish (US)
Article number68003
JournalEPL
Volume91
Issue number6
DOIs
StatePublished - Sep 1 2010

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filaments
polynomials
nucleation
expansion

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Filament turnover stabilizes contractile cytoskeletal structures. / Guthardt Torres, P.; Doubrovinski, K.; Kruse, K.

In: EPL, Vol. 91, No. 6, 68003, 01.09.2010.

Research output: Contribution to journalArticle

Guthardt Torres, P. ; Doubrovinski, K. ; Kruse, K. / Filament turnover stabilizes contractile cytoskeletal structures. In: EPL. 2010 ; Vol. 91, No. 6.
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