Finding a niche

Studies from the Drosophila ovary

Susan Eliazer, Michael Buszczak

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Specialized microenvironments called niches help maintain stem cells in an undifferentiated and self-renewing state. The existence of niches has long been predicted from mammalian studies, but identifying stem cells in their native environments in vivo has remained a challenge in most vertebrates. Many of the mechanistic insights into how niches regulate stem cell maintenance have been obtained using invertebrate models such as Drosophila. Here, we focus on the Drosophila ovarian germline stem cell niche and review recent studies that have begun to reveal how intricate crosstalk between various signaling pathways regulates stem cell maintenance, how the extracellular matrix modulates the signaling output of the niche and how epigenetic programming influences cell development and function both inside and outside the niche to ensure proper tissue homeostasis. These insights will probably inform the study of mammalian niches and how their malfunction contributes to human disease.

Original languageEnglish (US)
Article number45
JournalStem Cell Research and Therapy
Volume2
Issue number6
DOIs
StatePublished - 2011

Fingerprint

Stem cells
Drosophila
Stem Cell Niche
Ovary
Stem Cells
Maintenance
Invertebrates
Tissue homeostasis
Epigenomics
Extracellular Matrix
Vertebrates
Homeostasis
Crosstalk

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Medicine
  • Cell Biology
  • Medicine (miscellaneous)
  • Medicine(all)

Cite this

Finding a niche : Studies from the Drosophila ovary. / Eliazer, Susan; Buszczak, Michael.

In: Stem Cell Research and Therapy, Vol. 2, No. 6, 45, 2011.

Research output: Contribution to journalArticle

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