Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol

W. Frank Peacock, Alan S. Maisel, Christian Mueller, Stefan D. Anker, Fred S. Apple, Robert H. Christenson, Paul Collinson, Lori B. Daniels, Deborah B. Diercks, Salvatore Di Somma, Gerasimos Filippatos, Gary Headden, Brian Hiestand, Judd E. Hollander, Juan C. Kaski, Joshua M. Kosowsky, John T. Nagurney, Richard M. Nowak, Donald Schreiber, Gary M. VilkeMarvin A. Wayne, Martin Than

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To determine the utility of a highly sensitive troponin assay when utilized in the emergency department. Methods The FAST-TRAC study prospectively enrolled > 1,500 emergency department patients with suspected acute coronary syndrome within 6 hours of symptom onset and 2 hours of emergency department presentation. It has several unique features that are not found in the majority of studies evaluating troponin. These include a very early presenting population in whom pro-spective data collection of risk score parameters and the physician’s clinical impression of the probability of acute coronary syndrome before any troponin data were available. Furthermore, two gold standard diagnostic definitions were determined by a pair of cardiologists reviewing two separate data sets; one that included all local troponin testing results and a second that ex-cluded troponin testing so that diagnosis was based solely on clinical grounds. By this method, a statistically valid head-to-head comparison of contemporary and high sensitivity troponin testing is obtainable. Finally, because of a significant delay in sample processing, a unique ability to define the molecular stability of various troponin assays is possible. Trial registration ClinicalTrials.gov Identifier NCT00880802.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalClinical and Experimental Emergency Medicine
Volume9
Issue number2
DOIs
StatePublished - Jun 2022

Keywords

  • Acute coronary syndrome
  • Coronary artery disease
  • Emergency medicine
  • Myocardial infarction
  • Troponin

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency

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