TY - JOUR
T1 - Fine-tuning motor neuron properties
T2 - Signaling from the periphery
AU - Koo, Sonya J.
AU - Pfaff, Samuel L.
PY - 2002/8/29
Y1 - 2002/8/29
N2 - Our understanding of motor neuron differentiation is rapidly evolving. New studies demonstrate that cells in the periphery of the embryo provide feedback signals for spinal cord motor neurons that are instrumental in the timing and regulation of their development. Two papers in this issue of Neuron (Haase et al., 2002; Livet et al., 2002) identify a motor neuron survival factor, GDNF, and the ETS transcription factor, PEA3, as key components of a signal transduction pathway whose goals are 2-fold: to cluster motor pool-specific cell bodies and to promote axon arborization.
AB - Our understanding of motor neuron differentiation is rapidly evolving. New studies demonstrate that cells in the periphery of the embryo provide feedback signals for spinal cord motor neurons that are instrumental in the timing and regulation of their development. Two papers in this issue of Neuron (Haase et al., 2002; Livet et al., 2002) identify a motor neuron survival factor, GDNF, and the ETS transcription factor, PEA3, as key components of a signal transduction pathway whose goals are 2-fold: to cluster motor pool-specific cell bodies and to promote axon arborization.
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U2 - 10.1016/S0896-6273(02)00870-X
DO - 10.1016/S0896-6273(02)00870-X
M3 - Review article
C2 - 12372278
AN - SCOPUS:0037194903
SN - 0896-6273
VL - 35
SP - 823
EP - 826
JO - Neuron
JF - Neuron
IS - 5
ER -