Fine-tuning motor neuron properties: Signaling from the periphery

Sonya J. Koo, Samuel L. Pfaff

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Our understanding of motor neuron differentiation is rapidly evolving. New studies demonstrate that cells in the periphery of the embryo provide feedback signals for spinal cord motor neurons that are instrumental in the timing and regulation of their development. Two papers in this issue of Neuron (Haase et al., 2002; Livet et al., 2002) identify a motor neuron survival factor, GDNF, and the ETS transcription factor, PEA3, as key components of a signal transduction pathway whose goals are 2-fold: to cluster motor pool-specific cell bodies and to promote axon arborization.

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalNeuron
Volume35
Issue number5
DOIs
StatePublished - Aug 29 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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