Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice

Baowei Fei, Hesheng Wang, Raymond F. Muzic, Chris A. Flask, Denise K. Feyes, David L. Wilson, Jeffrey L. Duerk, Nancy L. Oleinick

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We are investigating imaging techniques to study the tumor response to photodynamic therapy (PDT). PET can provide physiological and functional information. High-resolution MRI can provide anatomical and morphological changes. Image registration can combine MRI and PET images for improved tumor monitoring. In this study, we acquired high-resolution MRI and microPET [ 18F]fluorodeoxyglucose (FDG) images from C3H mice with RIF-1 tumors that were treated with Pc 4-based PDT. For tumor registration, we developed a finite element model (FEM)-based deformable registration scheme. To assess the registration quality, we performed slice by slice review of both image volumes, computed the volume overlap ratios, and visualized both volumes in color overlay. The mean volume overlap ratios for tumors were 94.7% after registration. Registration of high-resolution MRI and microPET images combines anatomical and functional information of the tumors and provides a useful tool for evaluating photodynamic therapy.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2006
Subtitle of host publicationPhysiology, Function, and Structure from Medical Images
DOIs
StatePublished - Jun 30 2006
Externally publishedYes
EventMedical Imaging 2006: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 12 2006Feb 14 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6143 II
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2006: Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/12/062/14/06

Fingerprint

Photodynamic therapy
Photochemotherapy
mice
Tumors
therapy
tumors
Magnetic resonance imaging
high resolution
Neoplasms
Inbred C3H Mouse
Image registration
Fluorodeoxyglucose F18
imaging techniques
Color
color
Imaging techniques
Monitoring

Keywords

  • Cancer
  • Cellular and molecular imaging
  • Deformable image registration
  • Finite element model
  • Photodynamic therapy
  • Small animal imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Fei, B., Wang, H., Muzic, R. F., Flask, C. A., Feyes, D. K., Wilson, D. L., ... Oleinick, N. L. (2006). Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice. In Medical Imaging 2006: Physiology, Function, and Structure from Medical Images [61433I] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6143 II). https://doi.org/10.1117/12.649531

Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice. / Fei, Baowei; Wang, Hesheng; Muzic, Raymond F.; Flask, Chris A.; Feyes, Denise K.; Wilson, David L.; Duerk, Jeffrey L.; Oleinick, Nancy L.

Medical Imaging 2006: Physiology, Function, and Structure from Medical Images. 2006. 61433I (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6143 II).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fei, B, Wang, H, Muzic, RF, Flask, CA, Feyes, DK, Wilson, DL, Duerk, JL & Oleinick, NL 2006, Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice. in Medical Imaging 2006: Physiology, Function, and Structure from Medical Images., 61433I, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6143 II, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 2/12/06. https://doi.org/10.1117/12.649531
Fei B, Wang H, Muzic RF, Flask CA, Feyes DK, Wilson DL et al. Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice. In Medical Imaging 2006: Physiology, Function, and Structure from Medical Images. 2006. 61433I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.649531
Fei, Baowei ; Wang, Hesheng ; Muzic, Raymond F. ; Flask, Chris A. ; Feyes, Denise K. ; Wilson, David L. ; Duerk, Jeffrey L. ; Oleinick, Nancy L. / Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice. Medical Imaging 2006: Physiology, Function, and Structure from Medical Images. 2006. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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AU - Feyes, Denise K.

AU - Wilson, David L.

AU - Duerk, Jeffrey L.

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