First Demonstration of Combined kV/MV Image-Guided Real-Time Dynamic Multileaf-Collimator Target Tracking

Byungchul Cho, Per R. Poulsen, Alex Sloutsky, Amit Sawant, Paul J. Keall

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Purpose: For intrafraction motion management, a real-time tracking system was developed by combining fiducial marker-based tracking via simultaneous kilovoltage (kV) and megavoltage (MV) imaging and a dynamic multileaf collimator (DMLC) beam-tracking system. Methods and Materials: The integrated tracking system employed a Varian Trilogy system equipped with kV/MV imaging systems and a Millennium 120-leaf MLC. A gold marker in elliptical motion (2-cm superior-inferior, 1-cm left-right, 10 cycles/min) was simultaneously imaged by the kV and MV imagers at 6.7 Hz and segmented in real time. With these two-dimensional projections, the tracking software triangulated the three-dimensional marker position and repositioned the MLC leaves to follow the motion. Phantom studies were performed to evaluate time delay from image acquisition to MLC adjustment, tracking error, and dosimetric impact of target motion with and without tracking. Results: The time delay of the integrated tracking system was ∼450 ms. The tracking error using a prediction algorithm was 0.9 ± 0.5 mm for the elliptical motion. The dose distribution with tracking showed better target coverage and less dose to surrounding region over no tracking. The failure rate of the gamma test (3%/3-mm criteria) was 22.5% without tracking but was reduced to 0.2% with tracking. Conclusion: For the first time, a complete tracking system combining kV/MV image-guided target tracking and DMLC beam tracking was demonstrated. The average geometric error was less than 1 mm, and the dosimetric error was negligible. This system is a promising method for intrafraction motion management.

Original languageEnglish (US)
Pages (from-to)859-867
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume74
Issue number3
DOIs
StatePublished - Jul 1 2009

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collimators
Fiducial Markers
Computer Systems
markers
Gold
Software
leaves
time lag
dosage
acquisition

Keywords

  • Dynamic multileaf collimator
  • Intrafraction motion management
  • Real-time tumor tracking
  • X-ray image guidance

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

First Demonstration of Combined kV/MV Image-Guided Real-Time Dynamic Multileaf-Collimator Target Tracking. / Cho, Byungchul; Poulsen, Per R.; Sloutsky, Alex; Sawant, Amit; Keall, Paul J.

In: International Journal of Radiation Oncology Biology Physics, Vol. 74, No. 3, 01.07.2009, p. 859-867.

Research output: Contribution to journalArticle

Cho, Byungchul ; Poulsen, Per R. ; Sloutsky, Alex ; Sawant, Amit ; Keall, Paul J. / First Demonstration of Combined kV/MV Image-Guided Real-Time Dynamic Multileaf-Collimator Target Tracking. In: International Journal of Radiation Oncology Biology Physics. 2009 ; Vol. 74, No. 3. pp. 859-867.
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abstract = "Purpose: For intrafraction motion management, a real-time tracking system was developed by combining fiducial marker-based tracking via simultaneous kilovoltage (kV) and megavoltage (MV) imaging and a dynamic multileaf collimator (DMLC) beam-tracking system. Methods and Materials: The integrated tracking system employed a Varian Trilogy system equipped with kV/MV imaging systems and a Millennium 120-leaf MLC. A gold marker in elliptical motion (2-cm superior-inferior, 1-cm left-right, 10 cycles/min) was simultaneously imaged by the kV and MV imagers at 6.7 Hz and segmented in real time. With these two-dimensional projections, the tracking software triangulated the three-dimensional marker position and repositioned the MLC leaves to follow the motion. Phantom studies were performed to evaluate time delay from image acquisition to MLC adjustment, tracking error, and dosimetric impact of target motion with and without tracking. Results: The time delay of the integrated tracking system was ∼450 ms. The tracking error using a prediction algorithm was 0.9 ± 0.5 mm for the elliptical motion. The dose distribution with tracking showed better target coverage and less dose to surrounding region over no tracking. The failure rate of the gamma test (3{\%}/3-mm criteria) was 22.5{\%} without tracking but was reduced to 0.2{\%} with tracking. Conclusion: For the first time, a complete tracking system combining kV/MV image-guided target tracking and DMLC beam tracking was demonstrated. The average geometric error was less than 1 mm, and the dosimetric error was negligible. This system is a promising method for intrafraction motion management.",
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