Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice

M. Sri Balasubashini, S. Karthigayan, S. T. Somasundaram, T. Balasubramanian, V. Viswanathan, P. Raveendran, V. P. Menon

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich's ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.

Original languageEnglish (US)
Pages (from-to)6219-6225
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number24
DOIs
StatePublished - Dec 15 2006

Keywords

  • Fish venom
  • PCNA
  • Tumor metastasis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Sri Balasubashini, M., Karthigayan, S., Somasundaram, S. T., Balasubramanian, T., Viswanathan, V., Raveendran, P., & Menon, V. P. (2006). Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice. Bioorganic and Medicinal Chemistry Letters, 16(24), 6219-6225. https://doi.org/10.1016/j.bmcl.2006.09.025