Five vs ten days' therapy with furazolidone for giardiasis

T. V. Murphy, J. D. Nelson

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

In previous uncontrolled studies it has been reported that five days' treatment with furazolidone is effective for giardiasis. Efficacy of five vs ten days of treatment was evaluated in a prospective, randomized study of 22 children with giardiasis. Eleven of 12 patients (92%) treated for ten days were cured based on clinical and parasitological response; one patient did not tolerate furazolidone and was treated with quinacrine hydrochloride. Only two of ten patients (20%) treated with a five-day regimen were cured. Of the other eight patients, five had prompt relapse of diarrhea after furazolidone treatment was stopped, diarrhea persisted in two, and diarrhea diminished but Giardia persisted in one. Six of eight patients in whom the five-day regimen failed were re-treated with furazolidone for ten days, and five patients were cured. Therapy with furazolidone for less than seven to ten days cannot be recommended for children with giardiasis.

Original languageEnglish (US)
Pages (from-to)267-270
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume137
Issue number3
StatePublished - 1983

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Furazolidone
Giardiasis
Diarrhea
Therapeutics
Giardia
Quinacrine
Prospective Studies
Recurrence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Five vs ten days' therapy with furazolidone for giardiasis. / Murphy, T. V.; Nelson, J. D.

In: American Journal of Diseases of Children, Vol. 137, No. 3, 1983, p. 267-270.

Research output: Contribution to journalArticle

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