Fixed maximal stroke index in patients after pneumonectomy

O. M. Hijazi, M. Ramanathan, A. S. Estrera, Ronald M Peshock, Connie C Hsia

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Abstract

Patients who have undergone pneumonectomy (PNX) show limited exercise capacity, partly attributable to an impaired stroke index (SI). To determine whether this limitation is due to deconditioning, we assessed exercise performance and cardiopulmonary function in seven patients after PNX (age: 59 ± 2 yr, mean ± SEM) and eight normal, healthy nonsmokers (52 ± 3 yr) before and after an ergometer exercise training program for 30 min per day, 5 d per week, for 8 wk at 65% of measured maximal O2 uptake. Lung volume, diffusing capacity of carbon dioxide (DL(CO)) and cardiac index (CI) were determined during steady-state exercise by a rebreathing method. Exercise endurance was measured at 80% of maximal power. As compared with normal subjects, patients who had had PNX showed diminished maximal oxygen uptake (V̇o(2max), as well as diminished lung volumes, ventilatory capacities, and maximal cardiac and stroke indexes. After training, V̇o(2max), endurance, and peripheral O2 extraction improved in both groups. However, maximal cardiac and stroke indexes increased only in normal subjects and not in patients. We conclude that an irreversibly fixed maximal SI is a major source of exercise limitation after PNX, probably because of pulmonary arterial hypertension and/or mechanical distortion of the cardiac fossa. Ventilatory impairment after PNX did not prevent a training-induced increase in V̇o(2max). Exercise training confers significant functional benefit on postpneumonectomy patients by enhancing peripheral O2 extraction.

Original languageEnglish (US)
Pages (from-to)1623-1629
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume157
Issue number5 I
StatePublished - 1998

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Pneumonectomy
Stroke
Exercise
Lung
Carbon Monoxide
Pulmonary Hypertension
Carbon Dioxide
Oxygen
Education

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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Fixed maximal stroke index in patients after pneumonectomy. / Hijazi, O. M.; Ramanathan, M.; Estrera, A. S.; Peshock, Ronald M; Hsia, Connie C.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 157, No. 5 I, 1998, p. 1623-1629.

Research output: Contribution to journalArticle

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