Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

George R. Wendt, Julie Nr Collins, Jimin Pei, Mark S. Pearson, Hayley M. Bennett, Alex Loukas, Matthew Berriman, Nick V. Grishin, James J. Collins

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Schistosomes infect more than 200 million people. These parasitic flatworms rely on a syncytial outer coat called the tegument to survive within the vasculature of their host. Although the tegument is pivotal for their survival, little is known about maintenance of this tissue during the decades schistosomes survive in the bloodstream. Here, we demonstrate that the tegument relies on stem cells (neoblasts) to specify fusogenic progenitors that replace tegumental cells lost to turnover. Molecular characterization of neoblasts and tegumental progenitors led to the discovery of two flatworm-specific zinc finger proteins that are essential for tegumental cell specification. These proteins are homologous to a protein essential for neoblast-driven epidermal maintenance in free-living flatworms. Therefore, we speculate that related parasites (i.e., tapeworms and flukes) employ similar strategies to control tegumental maintenance. Since parasitic flatworms infect every vertebrate species, understanding neoblast-driven tegumental maintenance could identify broad-spectrum therapeutics to fight diseases caused by these parasites.

Original languageEnglish (US)
JournaleLife
Volume7
DOIs
StatePublished - Mar 20 2018

Fingerprint

Platyhelminths
Schistosoma mansoni
Maintenance
Specifications
Parasites
Trematoda
Proteins
Cestoda
Zinc Fingers
Stem cells
Vertebrates
Zinc
Stem Cells
Tissue

Keywords

  • developmental biology
  • infectious disease
  • microbiology
  • none
  • Schistosoma mansoni
  • stem cell
  • stem cells
  • tegument

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni. / Wendt, George R.; Collins, Julie Nr; Pei, Jimin; Pearson, Mark S.; Bennett, Hayley M.; Loukas, Alex; Berriman, Matthew; Grishin, Nick V.; Collins, James J.

In: eLife, Vol. 7, 20.03.2018.

Research output: Contribution to journalArticle

Wendt, George R. ; Collins, Julie Nr ; Pei, Jimin ; Pearson, Mark S. ; Bennett, Hayley M. ; Loukas, Alex ; Berriman, Matthew ; Grishin, Nick V. ; Collins, James J. / Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni. In: eLife. 2018 ; Vol. 7.
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AU - Bennett, Hayley M.

AU - Loukas, Alex

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