Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!

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Abstract

The mechanism for flipping large lipid-linked oligosaccharides across membranes has remained a paradox. Perez. et al. now report the structure of the PglK protein of. C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.

Original languageEnglish (US)
JournalTrends in Biochemical Sciences
DOIs
Publication statusAccepted/In press - 2015

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Keywords

  • Dolichol
  • Flippase
  • Lipid-linked oligosaccharide
  • Polyisoprenol
  • Undecaprenol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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