Flipping a Lipid-Linked Oligosaccharide? You Must Whip It

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

The mechanism for flipping large lipid-linked oligosaccharides across membranes has remained a paradox. Perez et al. now report the structure of the PglK protein of C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.

Original languageEnglish (US)
Pages (from-to)715-717
Number of pages3
JournalTrends in biochemical sciences
Volume40
Issue number12
DOIs
StatePublished - 2015

Keywords

  • Dolichol
  • Flippase
  • Lipid-linked oligosaccharide
  • Polyisoprenol
  • Undecaprenol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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