Fluorescence lifetime imaging of cancer in vivo

Owen Peng, Walter J. Akers

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Optical imaging of fluorescent reporters in animal models of cancer has become a common tool in oncologic research. Fluorescent reporters including fluorescent proteins, organic dyes, and inorganic photonic materials are used in fluorescence spectroscopy, microscopy, and whole body preclinical imaging. Fluorescence lifetime imaging provides additional, quantitative information beyond that of conventional fluorescence intensity signals, enabling signal multiplexing, background separation, and biological sensing unique to fluorescent materials.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages55-66
Number of pages12
DOIs
StatePublished - 2016
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1444
ISSN (Print)1064-3745

Keywords

  • Animal model
  • Diffuse spectroscopy
  • Drug delivery
  • Microenvironment
  • Molecular imaging
  • Oncology
  • Optical
  • Preclinical
  • Time-domain

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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