Fluorescent probes for monitoring regulated secretion

Wen Hong Li, Daliang Li

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Numerous secretory cells use the regulated secretory pathway to release signaling molecules. Regulated secretion is an essential component of the intercellular communication network of a multicellular organism and serves diverse functions in neurobiology, endocrinology, and many other aspects of animal physiology. Probes that can monitor a specific exocytotic event with high temporal and spatial resolution would be invaluable tools for studying the molecular and cellular mechanisms underlying stimulus-secretion coupling, and for characterizing secretion defects that are found in different human diseases. This review summarizes different strategies and recent progress in developing fluorescent sensors for imaging regulated cell secretion.

Original languageEnglish (US)
Pages (from-to)672-681
Number of pages10
JournalCurrent Opinion in Chemical Biology
Volume17
Issue number4
DOIs
Publication statusPublished - Aug 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry

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