Fluorescent probes for monitoring regulated secretion

Wen Hong Li; Daliang Li

doi:10.1016/j.cbpa.2013.04.026

Fluorescent probes for monitoring regulated secretion

Wen Hong Li, Daliang Li

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Numerous secretory cells use the regulated secretory pathway to release signaling molecules. Regulated secretion is an essential component of the intercellular communication network of a multicellular organism and serves diverse functions in neurobiology, endocrinology, and many other aspects of animal physiology. Probes that can monitor a specific exocytotic event with high temporal and spatial resolution would be invaluable tools for studying the molecular and cellular mechanisms underlying stimulus-secretion coupling, and for characterizing secretion defects that are found in different human diseases. This review summarizes different strategies and recent progress in developing fluorescent sensors for imaging regulated cell secretion.

Original language	English (US)
Pages (from-to)	672-681
Number of pages	10
Journal	Current Opinion in Chemical Biology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.cbpa.2013.04.026
State	Published - Aug 2013

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1016/j.cbpa.2013.04.026

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title = "Fluorescent probes for monitoring regulated secretion",

abstract = "Numerous secretory cells use the regulated secretory pathway to release signaling molecules. Regulated secretion is an essential component of the intercellular communication network of a multicellular organism and serves diverse functions in neurobiology, endocrinology, and many other aspects of animal physiology. Probes that can monitor a specific exocytotic event with high temporal and spatial resolution would be invaluable tools for studying the molecular and cellular mechanisms underlying stimulus-secretion coupling, and for characterizing secretion defects that are found in different human diseases. This review summarizes different strategies and recent progress in developing fluorescent sensors for imaging regulated cell secretion.",

author = "Li, {Wen Hong} and Daliang Li",

note = "Funding Information: We thank the financial supports from NIH (grant R01-GM077593 ) and Juvenile Diabetes Research Foundation (grant 37-2011-21 ). This work was performed in laboratories constructed with support from NIH grant C06 RR30414 . ",

year = "2013",

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doi = "10.1016/j.cbpa.2013.04.026",

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AU - Li, Wen Hong

AU - Li, Daliang

N1 - Funding Information: We thank the financial supports from NIH (grant R01-GM077593 ) and Juvenile Diabetes Research Foundation (grant 37-2011-21 ). This work was performed in laboratories constructed with support from NIH grant C06 RR30414 .

PY - 2013/8

Y1 - 2013/8

N2 - Numerous secretory cells use the regulated secretory pathway to release signaling molecules. Regulated secretion is an essential component of the intercellular communication network of a multicellular organism and serves diverse functions in neurobiology, endocrinology, and many other aspects of animal physiology. Probes that can monitor a specific exocytotic event with high temporal and spatial resolution would be invaluable tools for studying the molecular and cellular mechanisms underlying stimulus-secretion coupling, and for characterizing secretion defects that are found in different human diseases. This review summarizes different strategies and recent progress in developing fluorescent sensors for imaging regulated cell secretion.

AB - Numerous secretory cells use the regulated secretory pathway to release signaling molecules. Regulated secretion is an essential component of the intercellular communication network of a multicellular organism and serves diverse functions in neurobiology, endocrinology, and many other aspects of animal physiology. Probes that can monitor a specific exocytotic event with high temporal and spatial resolution would be invaluable tools for studying the molecular and cellular mechanisms underlying stimulus-secretion coupling, and for characterizing secretion defects that are found in different human diseases. This review summarizes different strategies and recent progress in developing fluorescent sensors for imaging regulated cell secretion.

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Fluorescent probes for monitoring regulated secretion

Abstract

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