Fluorinated macromolecular probes for non-invasive assessment of pH by Magnetic resonance spectroscopy

V. D. Mehta; P. V. Kulkarni; R. P. Mason; P. P. Antich

doi:10.1016/S0960-894X(01)80874-X

Fluorinated macromolecular probes for non-invasive assessment of pH by Magnetic resonance spectroscopy

V. D. Mehta, P. V. Kulkarni, R. P. Mason, P. P. Antich

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with ¹⁹F Magnetic Resonance Spectroscopy (¹⁹F MRS). 3-Fluorosalicyl-aldehyde (3-FSA) has been employed as a prototype ¹⁹F pH indicator to conjugate to carrier molecules (polyamino dextran, polylysine and albumin). These 3-FSA polymer conjugates exhibit single sharp ¹⁹F signal, moderate ¹⁹F pH sensitivity, and the physiological pKa necessary for in vivo measurement of pH by ¹⁹F MRS. Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with ¹⁹F Magnetic Resonance Spectroscopy (¹⁹F MRS). 3-Fluorosalicyl-aldehyde has been employed as a prototype ¹⁹F pH indicator to conjugate to carrier polymers. These polymer-3-FSA conjugates exhibit a single sharp ¹⁹F signal, moderate ¹⁹F pH sensitivity, and physiological pKa necessary for in vivo measurement of pH by ¹⁹F MRS.

Original language	English (US)
Pages (from-to)	187-192
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(01)80874-X
State	Published - Feb 1993

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(01)80874-X

Cite this

@article{9a179e25742247a6b1d8518ba6ede5fb,

title = "Fluorinated macromolecular probes for non-invasive assessment of pH by Magnetic resonance spectroscopy",

abstract = "Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde (3-FSA) has been employed as a prototype 19F pH indicator to conjugate to carrier molecules (polyamino dextran, polylysine and albumin). These 3-FSA polymer conjugates exhibit single sharp 19F signal, moderate 19F pH sensitivity, and the physiological pKa necessary for in vivo measurement of pH by 19F MRS. Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde has been employed as a prototype 19F pH indicator to conjugate to carrier polymers. These polymer-3-FSA conjugates exhibit a single sharp 19F signal, moderate 19F pH sensitivity, and physiological pKa necessary for in vivo measurement of pH by 19F MRS.",

author = "Mehta, {V. D.} and Kulkarni, {P. V.} and Mason, {R. P.} and Antich, {P. P.}",

year = "1993",

month = feb,

doi = "10.1016/S0960-894X(01)80874-X",

language = "English (US)",

volume = "3",

pages = "187--192",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Fluorinated macromolecular probes for non-invasive assessment of pH by Magnetic resonance spectroscopy

AU - Mehta, V. D.

AU - Kulkarni, P. V.

AU - Mason, R. P.

AU - Antich, P. P.

PY - 1993/2

Y1 - 1993/2

N2 - Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde (3-FSA) has been employed as a prototype 19F pH indicator to conjugate to carrier molecules (polyamino dextran, polylysine and albumin). These 3-FSA polymer conjugates exhibit single sharp 19F signal, moderate 19F pH sensitivity, and the physiological pKa necessary for in vivo measurement of pH by 19F MRS. Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde has been employed as a prototype 19F pH indicator to conjugate to carrier polymers. These polymer-3-FSA conjugates exhibit a single sharp 19F signal, moderate 19F pH sensitivity, and physiological pKa necessary for in vivo measurement of pH by 19F MRS.

AB - Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde (3-FSA) has been employed as a prototype 19F pH indicator to conjugate to carrier molecules (polyamino dextran, polylysine and albumin). These 3-FSA polymer conjugates exhibit single sharp 19F signal, moderate 19F pH sensitivity, and the physiological pKa necessary for in vivo measurement of pH by 19F MRS. Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde has been employed as a prototype 19F pH indicator to conjugate to carrier polymers. These polymer-3-FSA conjugates exhibit a single sharp 19F signal, moderate 19F pH sensitivity, and physiological pKa necessary for in vivo measurement of pH by 19F MRS.

UR - http://www.scopus.com/inward/record.url?scp=0027477287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027477287&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(01)80874-X

DO - 10.1016/S0960-894X(01)80874-X

M3 - Article

AN - SCOPUS:0027477287

SN - 0960-894X

VL - 3

SP - 187

EP - 192

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Fluorinated macromolecular probes for non-invasive assessment of pH by Magnetic resonance spectroscopy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this