Fluorinated macromolecular probes for non-invasive assessment of pH by Magnetic resonance spectroscopy

V. D. Mehta, P. V. Kulkarni, R. P. Mason, P. P. Antich

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde (3-FSA) has been employed as a prototype 19F pH indicator to conjugate to carrier molecules (polyamino dextran, polylysine and albumin). These 3-FSA polymer conjugates exhibit single sharp 19F signal, moderate 19F pH sensitivity, and the physiological pKa necessary for in vivo measurement of pH by 19F MRS. Fluorinated polymeric molecular probes have been synthesized and characterized for non invasive assessment of pH with 19F Magnetic Resonance Spectroscopy (19F MRS). 3-Fluorosalicyl-aldehyde has been employed as a prototype 19F pH indicator to conjugate to carrier polymers. These polymer-3-FSA conjugates exhibit a single sharp 19F signal, moderate 19F pH sensitivity, and physiological pKa necessary for in vivo measurement of pH by 19F MRS.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number2
DOIs
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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