Fluorine-18 fluorodeoxyglucose splenic uptake from extramedullary hematopoiesis after granulocyte colony-stimulating factor stimulation

Hussein M. Abdel-Dayem, Gerald Rosen, Hossam El-Zeftawy, Sleiman Naddaf, Mithilesh Kumar, Saadet Atay, Adrienne Cacavio

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Two patients with sarcoma, one with recurrent osteosarcoma of the spine and the other with metastatic synovial cell sarcoma, were treated with high- dose chemotherapy that produced severe leukopenia. The patients received granulocyte colony-stimulating factor (G-CSF) to stimulate the bone marrow (480 mg given subcutaneously twice daily for 5 to 7 days); their responses were seen as a marked increase in peripheral leukocyte count with no change in the erythrocyte or platelet counts. The patients had fluorine-18 fluorodeoxygluclose (F-18 FDG) imaging 24 hours after the end of G-CSF treatment. Diffusely increased uptake of F-18 FDG was seen in the bone marrow in both patients. In addition, markedly increased uptake in the spleen was noted in both, indicating that the spleen was the site of extramedullary hematopoiesis. The patients had no evidence of splenic metastases. The first patient had a history of irradiation to the dorsal spine, which was less responsive to G-CSF administration than was the nonirradiated lumbar spine.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalClinical Nuclear Medicine
Volume24
Issue number5
DOIs
StatePublished - May 1999

Fingerprint

Extramedullary Hematopoiesis
Fluorodeoxyglucose F18
Granulocyte Colony-Stimulating Factor
Spine
Fluorine
Spleen
Bone Marrow
Synovial Sarcoma
Erythrocyte Count
Leukopenia
Osteosarcoma
Platelet Count
Leukocyte Count
Sarcoma
Neoplasm Metastasis
Drug Therapy

Keywords

  • Bone marrow hyperplasia
  • Extramedullary hematopoiesis
  • Fluorine-18 fluorodeoxygluclose
  • Granulocyte colony-stimulating Factor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Fluorine-18 fluorodeoxyglucose splenic uptake from extramedullary hematopoiesis after granulocyte colony-stimulating factor stimulation. / Abdel-Dayem, Hussein M.; Rosen, Gerald; El-Zeftawy, Hossam; Naddaf, Sleiman; Kumar, Mithilesh; Atay, Saadet; Cacavio, Adrienne.

In: Clinical Nuclear Medicine, Vol. 24, No. 5, 05.1999, p. 319-322.

Research output: Contribution to journalArticle

Abdel-Dayem, Hussein M. ; Rosen, Gerald ; El-Zeftawy, Hossam ; Naddaf, Sleiman ; Kumar, Mithilesh ; Atay, Saadet ; Cacavio, Adrienne. / Fluorine-18 fluorodeoxyglucose splenic uptake from extramedullary hematopoiesis after granulocyte colony-stimulating factor stimulation. In: Clinical Nuclear Medicine. 1999 ; Vol. 24, No. 5. pp. 319-322.
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