TY - JOUR
T1 - FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia
AU - Parcells, Bertrand W.
AU - Ikeda, Alan K.
AU - Simms-Waldrip, Tiffany
AU - Moore, Theodore B.
AU - Sakamoto, Kathleen M.
PY - 2006/5
Y1 - 2006/5
N2 - Ligand-mediated activation of the FMS-like tyrosine kinase 3 (FLT3) receptor is important for normal proliferation of primitive hematopoietic cells. However, activating mutations in FLT3 induce ligand-independent downstream signaling that promotes oncogenesis through pathways involved in proliferation, differentiation, and survival. FLT3 mutations are identified as the most frequent genetic abnormality in acute myeloid leukemia and are also observed in other leukemias. Multiple small-molecule inhibitors are under development to target aberrant FLT3 activity that confers a poor prognosis in patients.
AB - Ligand-mediated activation of the FMS-like tyrosine kinase 3 (FLT3) receptor is important for normal proliferation of primitive hematopoietic cells. However, activating mutations in FLT3 induce ligand-independent downstream signaling that promotes oncogenesis through pathways involved in proliferation, differentiation, and survival. FLT3 mutations are identified as the most frequent genetic abnormality in acute myeloid leukemia and are also observed in other leukemias. Multiple small-molecule inhibitors are under development to target aberrant FLT3 activity that confers a poor prognosis in patients.
KW - Acute myeloid leukemia
KW - FMS-like tyrosine kinase 3
KW - Hematopoiesis
KW - Internal tandem duplication
KW - Small molecule inhibitor
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UR - http://www.scopus.com/inward/citedby.url?scp=33747332700&partnerID=8YFLogxK
U2 - 10.1634/stemcells.2005-0519
DO - 10.1634/stemcells.2005-0519
M3 - Review article
C2 - 16410383
AN - SCOPUS:33747332700
SN - 1066-5099
VL - 24
SP - 1174
EP - 1184
JO - STEM CELLS
JF - STEM CELLS
IS - 5
ER -