FNIRS-based evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy

Jianwei Cao, Bilal Khan, Nathan Hervey, Fenghua Tian, Mauricio R. Delgado, Nancy J. Clegg, Linsley Smith, Heather Roberts, Kirsten Tulchin-Francis, Angela Shierk, Laura Shagman, Duncan MacFarlane, Hanli Liu, George Alexandrakis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Sensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2 ± 2.1 years old) with hemiplegic cerebral palsy (CP) was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger tapping task were quantified before, immediately after, and six months after CIMT. Five age-matched healthy children (9.8 ± 1.3 years old) were also imaged at the same time points to provide comparative activation metrics for normal controls. In children with CP the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted six months later. In contrast to this longer term improvement in localized activation response, the laterality index that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed six months later.

Original languageEnglish (US)
Title of host publicationOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
EditorsHenry Hirschberg, Steen J. Madsen, Qingming Luo, Samarendra K. Mohanty, Nitish V. Thakor, E. Duco Jansen
PublisherSPIE
ISBN (Electronic)9781628413953
DOIs
StatePublished - Jan 1 2015
EventOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II - San Francisco, United States
Duration: Feb 7 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9305
ISSN (Print)1605-7422

Other

OtherOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
CountryUnited States
CitySan Francisco
Period2/7/152/10/15

Keywords

  • brain activation
  • cerebral palsy (CP)
  • constraint-induced movement therapy (CIMT)
  • functional near-infrared spectroscopy (fNIRS)
  • sensorimotor cortex

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Cao, J., Khan, B., Hervey, N., Tian, F., Delgado, M. R., Clegg, N. J., Smith, L., Roberts, H., Tulchin-Francis, K., Shierk, A., Shagman, L., MacFarlane, D., Liu, H., & Alexandrakis, G. (2015). FNIRS-based evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy. In H. Hirschberg, S. J. Madsen, Q. Luo, S. K. Mohanty, N. V. Thakor, & E. D. Jansen (Eds.), Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II [93050N] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9305). SPIE. https://doi.org/10.1117/12.2076995