Foetal vascular responses to thromboxane receptor blockade

B. A. Meyer; J. E. Dickinson; S. W. Walsh; V. M. Parisi

doi:10.1155/S0962935192000048

Foetal vascular responses to thromboxane receptor blockade

B. A. Meyer, J. E. Dickinson, S. W. Walsh, V. M. Parisi

Research output: Contribution to journal › Article › peer-review

Abstract

We hypothesized that foetal administration of SQ-29,548, a putative thromboxane receptor blocker, would prevent foeto-placental vasoconstriction produced by the thromboxane mimic U46619. Arterial blood gases, continuous monitoring of maternal and foetal heart rates and blood pressures were performed in chronically catheterized pregnant ewes. Foetal blood flows and vascular resistance were determined with radioactive microspheres. SQ-29,548 effectively blocked the expected vasoconstrictive effects of thromboxane. However, prolonged infusion of SQ-29,548 resulted in significant decreases in umbilical-placental blood flow and foetal mean arterial pressure. This was accompanied by a respiratory acidemia. Potential therapy for the vasoconstrictive disorders of pregnancy with SQ-29,548 awaits further investigation of its intrinsic vasoactive properties in the umbilical-placental vasculature.

Original language	English (US)
Pages (from-to)	15-21
Number of pages	7
Journal	Mediators of Inflammation
Volume	1
Issue number	1
DOIs	https://doi.org/10.1155/S0962935192000048
State	Published - 1992

Keywords

548
Foetal blood flow
Placental blood flow
SQ-29
Thromboxane receptor blockade
U46619

ASJC Scopus subject areas

Immunology
Cell Biology

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10.1155/S0962935192000048

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AU - Meyer, B. A.

AU - Dickinson, J. E.

AU - Walsh, S. W.

AU - Parisi, V. M.

PY - 1992

Y1 - 1992

N2 - We hypothesized that foetal administration of SQ-29,548, a putative thromboxane receptor blocker, would prevent foeto-placental vasoconstriction produced by the thromboxane mimic U46619. Arterial blood gases, continuous monitoring of maternal and foetal heart rates and blood pressures were performed in chronically catheterized pregnant ewes. Foetal blood flows and vascular resistance were determined with radioactive microspheres. SQ-29,548 effectively blocked the expected vasoconstrictive effects of thromboxane. However, prolonged infusion of SQ-29,548 resulted in significant decreases in umbilical-placental blood flow and foetal mean arterial pressure. This was accompanied by a respiratory acidemia. Potential therapy for the vasoconstrictive disorders of pregnancy with SQ-29,548 awaits further investigation of its intrinsic vasoactive properties in the umbilical-placental vasculature.

AB - We hypothesized that foetal administration of SQ-29,548, a putative thromboxane receptor blocker, would prevent foeto-placental vasoconstriction produced by the thromboxane mimic U46619. Arterial blood gases, continuous monitoring of maternal and foetal heart rates and blood pressures were performed in chronically catheterized pregnant ewes. Foetal blood flows and vascular resistance were determined with radioactive microspheres. SQ-29,548 effectively blocked the expected vasoconstrictive effects of thromboxane. However, prolonged infusion of SQ-29,548 resulted in significant decreases in umbilical-placental blood flow and foetal mean arterial pressure. This was accompanied by a respiratory acidemia. Potential therapy for the vasoconstrictive disorders of pregnancy with SQ-29,548 awaits further investigation of its intrinsic vasoactive properties in the umbilical-placental vasculature.

KW - 548

KW - Foetal blood flow

KW - Placental blood flow

KW - SQ-29

KW - Thromboxane receptor blockade

KW - U46619

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Foetal vascular responses to thromboxane receptor blockade

Abstract

Keywords

ASJC Scopus subject areas

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