Food restriction and fish oil suppress atherogenic risk factors in lupus-prone (NZB x NZW) F1 mice

Alagarraju Muthukumar, Khaliquz Zaman, Richard Lawrence, Jeffery L. Barnes, Gabriel Fernandes

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Atherosclerosis-mediated coronary artery disease is a significant cause of mortality in lupus patients. Both an activated immune system and hyperlipidemia are implicated in the pathogenesis of the atherosclerotic lesions of lupus. In this study, the increases in anticardiolipin antibodies, total cholesterol, and LDL cholesterol with age were significantly lowered by fish oil and food restriction, either alone or in combination. Food restriction also significantly decreased the elevation in anti-dsDNA antibody production seen with age in ad libitum groups. Interestingly, effects of food restriction and fish oil on both lipid profile and autoantibody production were seen from a young age. Accumulation of leukocytes in the blood vessels and deposition of IgG in the glomerular mesangium also were suppressed by food restriction. Thus, beneficial effects of fish oil and food restriction on lupus nephritis and survival could be, at least in part, due to their selective effect on atherogenic risk factors.

Original languageEnglish (US)
Pages (from-to)23-33
Number of pages11
JournalJournal of Clinical Immunology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2003

Keywords

  • Atherogenesis
  • Autoimmunity
  • Fish oil
  • Food restriction
  • Hypercholesterolemia
  • Hyperlipidemia
  • Lupus nephritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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