Forelimb Cortical Stroke Reduces Precision of Motor Control in Mice

April M. Becker, Dene M. Betz, Mark P. Goldberg

Research output: Contribution to journalArticle

Abstract

Background and Objective. Rodent models of stroke impairment should capture translatable features of behavioral injury. This study characterized poststroke impairment of motor precision separately from strength in an automated behavioral assay. Methods. We measured skilled distal forelimb reach-and-grasp motions within a target force range requiring moderate-strength. We assessed whether deficits reflected an increase in errors on only one or both sides of the target force range after photothrombotic cortical stroke. Results. Pull accuracy was impaired for 6 weeks after stroke, with errors redistributing to both sides of the target range. No decrease in maximum force was measured. Conclusions. This automated reach task measures sustained loss of motor precision following cortical stroke in mice.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalNeurorehabilitation and Neural Repair
Volume34
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • ischemic stroke
  • motor control
  • mouse
  • recovery
  • skilled reach
  • stroke

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

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