Formation of 5α-androstane-3α, 17β-diol by normal and hypertrophic human prostate

G. H. Jacobi, J. D. Wilson

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The 3-keto reduction of [l, 2-3H]dihydrotestosterone to 3α- and 3β-androstanediols was assessed in homogenates of 40 prostates obtained either at surgery or at medicolegal autopsy from men who had died suddenly. Formation of both androstanediols was demonstrable in cytosol and in microsomes, and both NADH and NADPH were effective cofactors for the two reactions. Formation of the two steroids was not influenced by storage of the gland for up to 8 h prior to processing. When NADPH was cofactor, the formation of 3α and 3β-androstanediol was significantly higher in microsomes and cytosol from hypertrophic than from normal glands.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume44
Issue number1
DOIs
StatePublished - Jan 1977

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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