Form(ul)ation of adipocytes by lipids

Kfir Lapid, Jonathan M. Graff

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Lipids have the potential to serve as bio-markers, which allow us to analyze and to identify cells under various experimental settings, and to serve as a clinical diagnostic tool. For example, diagnosis according to specific lipids that are associated with diabetes and obesity. The rapid development of mass-spectrometry techniques enables identification and profiling of multiple types of lipid species. Together, lipid profiling and data interpretation forge the new field of lipidomics. Lipidomics can be used to characterize physiologic and pathophysiological processes in adipocytes, since lipid metabolism is at the core of adipocyte physiology and energy homeostasis. A significant bulk of lipids are stored in adipocytes, which can be released and used to produce energy, used to build membranes, or used as signaling molecules that regulate metabolism. In this review, we discuss how exhaust of lipidomes can be used to study adipocyte differentiation, physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)176-186
Number of pages11
JournalAdipocyte
Volume6
Issue number3
DOIs
StatePublished - Jul 3 2017

Keywords

  • adipocytes
  • adipose stem cells
  • adipose tissue
  • bio-markers
  • differentiation
  • lipidomics
  • lipids

ASJC Scopus subject areas

  • Histology
  • Cell Biology

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