Forward and reverse genetic approaches to behavior in the mouse

Joseph S. Takahashi, Lawrence H. Pinto, Martha Hotz Vitaterna

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Abstract

Modern molecular genetic and genomic approaches are revolutionizing the study of behavior in the mouse. 'Reverse genetics' (from gene to phenotype) with targeted gene transfer provides a powerful tool to dissect behavior and has been used successfully to study the effects of null mutations in genes implicated in the regulation of long-term potentiation and spatial learning in mice. In addition, 'forward genetics' (from phenotype to gene) with high- efficiency mutagenesis in the mouse can uncover unknown genes and has been used to isolate a behavioral mutant of the circadian system. With the recent availability of high-density genetic maps and physical mapping resources, positional cloning of virtually any mutation is now feasible in the mouse. Together, these approaches permit a molecular analysis of both known and previously unknown genes regulating behavior.

Original languageEnglish (US)
Pages (from-to)1724-1733
Number of pages10
JournalScience
Volume264
Issue number5166
Publication statusPublished - Jun 17 1994

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Takahashi, J. S., Pinto, L. H., & Vitaterna, M. H. (1994). Forward and reverse genetic approaches to behavior in the mouse. Science, 264(5166), 1724-1733.