Forward and reverse genetic approaches to behavior in the mouse

Joseph S. Takahashi, Lawrence H. Pinto, Martha Hotz Vitaterna

Research output: Contribution to journalArticle

176 Scopus citations


Modern molecular genetic and genomic approaches are revolutionizing the study of behavior in the mouse. 'Reverse genetics' (from gene to phenotype) with targeted gene transfer provides a powerful tool to dissect behavior and has been used successfully to study the effects of null mutations in genes implicated in the regulation of long-term potentiation and spatial learning in mice. In addition, 'forward genetics' (from phenotype to gene) with high- efficiency mutagenesis in the mouse can uncover unknown genes and has been used to isolate a behavioral mutant of the circadian system. With the recent availability of high-density genetic maps and physical mapping resources, positional cloning of virtually any mutation is now feasible in the mouse. Together, these approaches permit a molecular analysis of both known and previously unknown genes regulating behavior.

Original languageEnglish (US)
Pages (from-to)1724-1733
Number of pages10
Issue number5166
Publication statusPublished - Jun 17 1994


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Cite this

Takahashi, J. S., Pinto, L. H., & Vitaterna, M. H. (1994). Forward and reverse genetic approaches to behavior in the mouse. Science, 264(5166), 1724-1733.