Forward genetic approaches to circadian clocks in mice

D. P. King, J. S. Takahashi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The study of mammalian circadian rhythms has a rich history of physiological understanding, but the molecular elements of the mammalian clock remain to be discovered. Availability of effective mutagenesis procedures and mouse molecular genetics resources sufficient for the task of positional cloning give cause for hope that the Clock gene, as well as other components of the mammalian circadian system, will be identified soon. The isolation of Clock in a deliberate mutagenesis screen provides an important proof-of-principle that forward genetics can be successfully applied toward the discovery of novel genes underlying complex behaviors in mice.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume61
StatePublished - 1996

Fingerprint

Circadian Clocks
mutagenesis
Mutagenesis
circadian rhythm
Clocks
mice
Genetic Association Studies
Circadian Rhythm
Genes
genetic resources
molecular genetics
Organism Cloning
Molecular Biology
molecular cloning
genes
Cloning
Availability
Genetics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Forward genetic approaches to circadian clocks in mice. / King, D. P.; Takahashi, J. S.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 61, 1996, p. 295-302.

Research output: Contribution to journalArticle

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