Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam

Yan Zhang, Olivier Van Reeth, Phyllis C. Zee, Joseph S. Takahashi, Fred W. Turek

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Recent studies have shown that light-induced phase shifts of the circadian rhythm of locomotor activity are associated with c-fos expression in the suprachiasmatic nucleus (SCN) and intergeniculate leaflet (IGL) of the lateral geniculate nucleus of rodents. In order to determine whether c-fos expression is necessary for the phase shifting effects of a non-photic stimulus, we assessed Fos-like immunoreactivity (Fos-lir) in the SCN and IGL at various times after an injection of the short-acting benzodiazepine, triazolam, at circadian time (CT) 6; i.e. at a time when triazolam induces an acute increase in locomotor activity and maximal phase advances in the circadian rhythm of locomotor activity. Specific Fos-lir staining was not observed in the SCN or IGL regions of any animals treated with triazolam or vehicle at any time point examined. These results indicate that exposure to an activity-inducing stimulus at circadian times when this stimulus induces phase shifts does not induce Fos protein synthesis in the SCN or IGL regions.

Original languageEnglish (US)
Pages (from-to)203-208
Number of pages6
JournalNeuroscience Letters
Volume164
Issue number1-2
DOIs
StatePublished - Dec 24 1993

Fingerprint

Triazolam
Circadian Clocks
Suprachiasmatic Nucleus
Locomotion
Circadian Rhythm
Proteins
Geniculate Bodies
Benzodiazepines
Rodentia
Staining and Labeling
Light
Injections

Keywords

  • Circadian clock
  • Fos immunoreactivity
  • Intergeniculate leaflet
  • Non-photic stimulus
  • Suprachiasmatic nucleus
  • Triazolam

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam. / Zhang, Yan; Van Reeth, Olivier; Zee, Phyllis C.; Takahashi, Joseph S.; Turek, Fred W.

In: Neuroscience Letters, Vol. 164, No. 1-2, 24.12.1993, p. 203-208.

Research output: Contribution to journalArticle

Zhang, Yan ; Van Reeth, Olivier ; Zee, Phyllis C. ; Takahashi, Joseph S. ; Turek, Fred W. / Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam. In: Neuroscience Letters. 1993 ; Vol. 164, No. 1-2. pp. 203-208.
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