Fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum

Jennifer A. Jordan, Nathan D. Schwade, John M. Truelson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Objectives: This study investigates the effect of fosfomycin on the tumoricidal efficacy of cisplatinum. Study Design: Prospective study utilizing the FaDu squamous cell carcinoma cell line and a nude mouse tumor xenograft model. Methods: Tumor cell growth was assessed in vitro in the presence of cisplatinum and/or fosfomycin utilizing the MTT assay. An optimal cisplatinum dose and dosing schedule was established in a nude mouse tumor xenograft model of squamous cell carcinoma. Using this model, fosfomycin was tested at three dosages and tumor growth monitored over 4 weeks. Results: Mice treated with cisplatinum and fosfomycin had smaller tumors than those treated with cisplatinum alone (P < .01). Conclusions: This study is the first demonstration that fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum in vivo. This suggests that fosfomycin may be useful in preventing cisplatinum-induced ototoxicity and nephrotoxicity in humans without altering the tumor response rate.

Original languageEnglish (US)
Pages (from-to)1259-1262
Number of pages4
JournalLaryngoscope
Volume109
Issue number8
DOIs
StatePublished - Aug 1 1999

Keywords

  • Cisplatinum
  • Fosfomycin
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

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