Four GABAergic interneurons impose feeding restraint in Drosophila

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establish a central feeding threshold which is required to inhibit consumption. Inactivation of these cells results in indiscriminate and excessive intake of all compounds, independent of taste quality or nutritional state. Conversely, acute activation of these neurons suppresses consumption of water and nutrients. The output from these neurons is required to gate activity in motor neurons that control meal initiation and consumption. Thus, our study reveals a layer of inhibitory control in feeding circuits that is required to suppress a latent state of unrestricted and nonselective consumption.

Original languageEnglish (US)
Pages (from-to)164-177
Number of pages14
JournalNeuron
Volume83
Issue number1
DOIs
StatePublished - Jul 2 2014
Externally publishedYes

Fingerprint

Dive into the research topics of 'Four GABAergic interneurons impose feeding restraint in Drosophila'. Together they form a unique fingerprint.

Cite this