Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease

Gong Qing Shen, Lin Li, Shaoqi Rao, Kalil G. Abdullah, Ji Min Ban, Bok Soo Lee, Jeong Euy Park, Qing K. Wang

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

OBJECTIVE - Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America. We aimed to determine whether this locus confers significant susceptibility to CAD in a South Korean population, and thus cross-race susceptibility to CAD. METHODS AND RESULTS - We performed a case-control association study with 611 unrelated CAD patients and 294 normal controls from South Korea. Allelic associations of SNPs and SNP haplotypes with CAD were evaluated. Multivariate logistic regression analysis was used to adjust effects of clinical covariates. We found that 4 SNPs on chromosome 9p21 were associated with susceptibility to CAD in a South Korean population. The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54). This represents the first study that expands association of these 9p21 SNPs with CAD beyond White populations. CONCLUSION - Chromosome 9p21 is an important susceptibility locus that confers high cross-race risk for development of CAD.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume28
Issue number2
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

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Genetic Loci
Single Nucleotide Polymorphism
Coronary Artery Disease
Chromosomes
Haplotypes
Population
North America
Republic of Korea
Genome-Wide Association Study
Case-Control Studies
Logistic Models
Myocardial Infarction
Regression Analysis

Keywords

  • Asian population
  • Association study
  • Coronary artery disease
  • Myocardial infarction
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. / Shen, Gong Qing; Li, Lin; Rao, Shaoqi; Abdullah, Kalil G.; Ban, Ji Min; Lee, Bok Soo; Park, Jeong Euy; Wang, Qing K.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, No. 2, 01.02.2008, p. 360-365.

Research output: Contribution to journalArticle

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AU - Shen, Gong Qing

AU - Li, Lin

AU - Rao, Shaoqi

AU - Abdullah, Kalil G.

AU - Ban, Ji Min

AU - Lee, Bok Soo

AU - Park, Jeong Euy

AU - Wang, Qing K.

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N2 - OBJECTIVE - Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America. We aimed to determine whether this locus confers significant susceptibility to CAD in a South Korean population, and thus cross-race susceptibility to CAD. METHODS AND RESULTS - We performed a case-control association study with 611 unrelated CAD patients and 294 normal controls from South Korea. Allelic associations of SNPs and SNP haplotypes with CAD were evaluated. Multivariate logistic regression analysis was used to adjust effects of clinical covariates. We found that 4 SNPs on chromosome 9p21 were associated with susceptibility to CAD in a South Korean population. The association remained significant after adjusting for significant clinical covariates (P=0.001 to 0.024). We identified one risk haplotype (GGGG; P=0.017) and one protective haplotype (AAAA; P=0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P=0.001 to 0.024; OR=2.37 to 1.54). This represents the first study that expands association of these 9p21 SNPs with CAD beyond White populations. CONCLUSION - Chromosome 9p21 is an important susceptibility locus that confers high cross-race risk for development of CAD.

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