Abstract
Twelve patients over one year old with neuroblastoma (NBL) metastatic to bone and bone marrow entered a study of adjuvant low-dose, fractionated total body irradiation (TBI). Six children who achieved a "complete clinical response" following chemotherapy (cyclophosphamide and adriamycin) and surgical resection of the abdominal primary received TBI (10 rad/fraction to totals of 100-120 rad/10-12 fx/12-25 days). Two children received concurrent local irradiation for residual abdominal tumor. The intervals from cessation of chemotherapy to documented progression ranged from 2-16 months, not substantially different from patients receiving similar chemotherapy and surgery without TBI. Three additional children with progressive NBL received similar TBI (80-120 rad/8-12 fx) without objective response.
Original language | English (US) |
---|---|
Pages (from-to) | 1599-1602 |
Number of pages | 4 |
Journal | International journal of radiation oncology, biology, physics |
Volume | 7 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1981 |
Keywords
- Neuroblastoma
- Total body irradiation
ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research