Fractionated total body irradiation for metastatic neuroblastoma

Larry E. Kun; James T. Casper; Robert W. Kline; Victoria D. Piaskowski

doi:10.1016/0360-3016(81)90092-4

Fractionated total body irradiation for metastatic neuroblastoma

Larry E. Kun, James T. Casper, Robert W. Kline, Victoria D. Piaskowski

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7 Scopus citations

Abstract

Twelve patients over one year old with neuroblastoma (NBL) metastatic to bone and bone marrow entered a study of adjuvant low-dose, fractionated total body irradiation (TBI). Six children who achieved a "complete clinical response" following chemotherapy (cyclophosphamide and adriamycin) and surgical resection of the abdominal primary received TBI (10 rad/fraction to totals of 100-120 rad/10-12 fx/12-25 days). Two children received concurrent local irradiation for residual abdominal tumor. The intervals from cessation of chemotherapy to documented progression ranged from 2-16 months, not substantially different from patients receiving similar chemotherapy and surgery without TBI. Three additional children with progressive NBL received similar TBI (80-120 rad/8-12 fx) without objective response.

Original language	English (US)
Pages (from-to)	1599-1602
Number of pages	4
Journal	International journal of radiation oncology, biology, physics
Volume	7
Issue number	11
DOIs	https://doi.org/10.1016/0360-3016(81)90092-4
State	Published - Nov 1981

Keywords

Neuroblastoma
Total body irradiation

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(81)90092-4

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@article{752550e838534934ad0b3a9d62f4b898,

title = "Fractionated total body irradiation for metastatic neuroblastoma",

abstract = "Twelve patients over one year old with neuroblastoma (NBL) metastatic to bone and bone marrow entered a study of adjuvant low-dose, fractionated total body irradiation (TBI). Six children who achieved a {"}complete clinical response{"} following chemotherapy (cyclophosphamide and adriamycin) and surgical resection of the abdominal primary received TBI (10 rad/fraction to totals of 100-120 rad/10-12 fx/12-25 days). Two children received concurrent local irradiation for residual abdominal tumor. The intervals from cessation of chemotherapy to documented progression ranged from 2-16 months, not substantially different from patients receiving similar chemotherapy and surgery without TBI. Three additional children with progressive NBL received similar TBI (80-120 rad/8-12 fx) without objective response.",

keywords = "Neuroblastoma, Total body irradiation",

author = "Kun, {Larry E.} and Casper, {James T.} and Kline, {Robert W.} and Piaskowski, {Victoria D.}",

note = "Funding Information: gy, The Medical College of Wisconsin, Milwaukee, WI 53226. TDepartment of Hematology/Oncology, Milwaukee Children{\textquoteright}s Hospital, Milwaukee, WI 52233. Supported in part by U. S. Public Health Service Grant, CA26226 from the National Cancer Institute, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Md.",

year = "1981",

month = nov,

doi = "10.1016/0360-3016(81)90092-4",

language = "English (US)",

volume = "7",

pages = "1599--1602",

journal = "International journal of radiation oncology, biology, physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Fractionated total body irradiation for metastatic neuroblastoma

AU - Kun, Larry E.

AU - Casper, James T.

AU - Kline, Robert W.

AU - Piaskowski, Victoria D.

N1 - Funding Information: gy, The Medical College of Wisconsin, Milwaukee, WI 53226. TDepartment of Hematology/Oncology, Milwaukee Children’s Hospital, Milwaukee, WI 52233. Supported in part by U. S. Public Health Service Grant, CA26226 from the National Cancer Institute, National Institutes of Health, Department of Health, Education and Welfare, Bethesda, Md.

PY - 1981/11

Y1 - 1981/11

N2 - Twelve patients over one year old with neuroblastoma (NBL) metastatic to bone and bone marrow entered a study of adjuvant low-dose, fractionated total body irradiation (TBI). Six children who achieved a "complete clinical response" following chemotherapy (cyclophosphamide and adriamycin) and surgical resection of the abdominal primary received TBI (10 rad/fraction to totals of 100-120 rad/10-12 fx/12-25 days). Two children received concurrent local irradiation for residual abdominal tumor. The intervals from cessation of chemotherapy to documented progression ranged from 2-16 months, not substantially different from patients receiving similar chemotherapy and surgery without TBI. Three additional children with progressive NBL received similar TBI (80-120 rad/8-12 fx) without objective response.

AB - Twelve patients over one year old with neuroblastoma (NBL) metastatic to bone and bone marrow entered a study of adjuvant low-dose, fractionated total body irradiation (TBI). Six children who achieved a "complete clinical response" following chemotherapy (cyclophosphamide and adriamycin) and surgical resection of the abdominal primary received TBI (10 rad/fraction to totals of 100-120 rad/10-12 fx/12-25 days). Two children received concurrent local irradiation for residual abdominal tumor. The intervals from cessation of chemotherapy to documented progression ranged from 2-16 months, not substantially different from patients receiving similar chemotherapy and surgery without TBI. Three additional children with progressive NBL received similar TBI (80-120 rad/8-12 fx) without objective response.

KW - Neuroblastoma

KW - Total body irradiation

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U2 - 10.1016/0360-3016(81)90092-4

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AN - SCOPUS:0019868930

SN - 0360-3016

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EP - 1602

JO - International journal of radiation oncology, biology, physics

JF - International journal of radiation oncology, biology, physics

IS - 11

ER -

Fractionated total body irradiation for metastatic neuroblastoma

Abstract

Keywords

ASJC Scopus subject areas

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