Fragile X mental retardation protein in plasticity and disease

Peter K. Todd, James S. Malter

Research output: Contribution to journalShort survey

14 Scopus citations

Abstract

Fragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome and the molecular mechanisms of learning and memory. We provide an overview of current concepts of how FMRP functions in the nervous system, with special emphasis on recent evidence that FMRP has a role in metabotropic glutamate receptor-activated protein translation and synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)623-630
Number of pages8
JournalJournal of Neuroscience Research
Volume70
Issue number5
DOIs
StatePublished - Dec 1 2002

Keywords

  • FMRP
  • Fragile X mental retardation protein
  • Fragile X syndrome

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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