TY - JOUR
T1 - Fragile x Syndrome and Alzheimer's disease
T2 - Another story about APP and β-Amyloid
AU - Malter, J. S.
AU - Ray, B. C.
AU - Westmark, P. R.
AU - Westmark, C. J.
PY - 2010/5
Y1 - 2010/5
N2 - As the mechanisms underlying neuronal development and degeneration become clarified, a number of common effectors and signaling pathways are becoming apparent. Here we describe the identification of Aβ, long considered a pathologic mediator of Alzheimers Disease and Down Syndrome, as similarly over-expressed in the neurodevelopmental disease, Fragile X Syndrome. We also show that mGluR5 inhibitors, currently employed for the treatment of Fragile X, reduce Aβ production in rodent models of Fragile X and AD as well as reduce disease phenotypes including seizures. Thus seemingly disparate neurologic diseases may share a common pathologic instigator and be treatable with a common, currently available class of therapeutics.
AB - As the mechanisms underlying neuronal development and degeneration become clarified, a number of common effectors and signaling pathways are becoming apparent. Here we describe the identification of Aβ, long considered a pathologic mediator of Alzheimers Disease and Down Syndrome, as similarly over-expressed in the neurodevelopmental disease, Fragile X Syndrome. We also show that mGluR5 inhibitors, currently employed for the treatment of Fragile X, reduce Aβ production in rodent models of Fragile X and AD as well as reduce disease phenotypes including seizures. Thus seemingly disparate neurologic diseases may share a common pathologic instigator and be treatable with a common, currently available class of therapeutics.
KW - Amyloid precursor protein (APP) and beta-amyloid
KW - Fragile x syndrome (FXS)
KW - Metabotropic glutamate receptors (mGluR)
UR - http://www.scopus.com/inward/record.url?scp=77952474914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952474914&partnerID=8YFLogxK
U2 - 10.2174/156720510791050957
DO - 10.2174/156720510791050957
M3 - Article
C2 - 20088809
AN - SCOPUS:77952474914
SN - 1567-2050
VL - 7
SP - 200
EP - 206
JO - Current Alzheimer research
JF - Current Alzheimer research
IS - 3
ER -