Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions

Elizabeth A. Cameron, Vanessa Sperandio

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The mammalian gastrointestinal (GI) microbiota is highly adapted to thrive in the GI environment and performs key functions related to host nutrition, physiology, development, immunity, and behavior. Successful host-bacterial associations require chemical signaling and optimal nutrient utilization and exchange. However, this important balance can be severely disrupted by environmental stimuli, with one of the most common insults upon the microbiota being infectious diseases. Although the microbiota acts as a barrier toward enteric pathogens, many enteric pathogens exploit signals and nutrients derived from both the microbiota and host to regulate their virulence programs. Here we review several signaling and nutrient recognition systems employed by GI pathogens to regulate growth and virulence. We discuss how shifts in the microbiota composition change host susceptibility to infection and how dietary changes or manipulation of the microbiota could potentially prevent and/or ameliorate GI infections.

Original languageEnglish (US)
Pages (from-to)275-284
Number of pages10
JournalCell Host and Microbe
Volume18
Issue number3
DOIs
StatePublished - Sep 9 2015

Fingerprint

Host-Pathogen Interactions
Microbiota
Food
Virulence
Nutritional Physiological Phenomena
Infection
Communicable Diseases
Immunity
Growth

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Frenemies : Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions. / Cameron, Elizabeth A.; Sperandio, Vanessa.

In: Cell Host and Microbe, Vol. 18, No. 3, 09.09.2015, p. 275-284.

Research output: Contribution to journalArticle

@article{3fd73e931a0648f18d0326215f868045,
title = "Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions",
abstract = "The mammalian gastrointestinal (GI) microbiota is highly adapted to thrive in the GI environment and performs key functions related to host nutrition, physiology, development, immunity, and behavior. Successful host-bacterial associations require chemical signaling and optimal nutrient utilization and exchange. However, this important balance can be severely disrupted by environmental stimuli, with one of the most common insults upon the microbiota being infectious diseases. Although the microbiota acts as a barrier toward enteric pathogens, many enteric pathogens exploit signals and nutrients derived from both the microbiota and host to regulate their virulence programs. Here we review several signaling and nutrient recognition systems employed by GI pathogens to regulate growth and virulence. We discuss how shifts in the microbiota composition change host susceptibility to infection and how dietary changes or manipulation of the microbiota could potentially prevent and/or ameliorate GI infections.",
author = "Cameron, {Elizabeth A.} and Vanessa Sperandio",
year = "2015",
month = "9",
day = "9",
doi = "10.1016/j.chom.2015.08.007",
language = "English (US)",
volume = "18",
pages = "275--284",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Frenemies

T2 - Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions

AU - Cameron, Elizabeth A.

AU - Sperandio, Vanessa

PY - 2015/9/9

Y1 - 2015/9/9

N2 - The mammalian gastrointestinal (GI) microbiota is highly adapted to thrive in the GI environment and performs key functions related to host nutrition, physiology, development, immunity, and behavior. Successful host-bacterial associations require chemical signaling and optimal nutrient utilization and exchange. However, this important balance can be severely disrupted by environmental stimuli, with one of the most common insults upon the microbiota being infectious diseases. Although the microbiota acts as a barrier toward enteric pathogens, many enteric pathogens exploit signals and nutrients derived from both the microbiota and host to regulate their virulence programs. Here we review several signaling and nutrient recognition systems employed by GI pathogens to regulate growth and virulence. We discuss how shifts in the microbiota composition change host susceptibility to infection and how dietary changes or manipulation of the microbiota could potentially prevent and/or ameliorate GI infections.

AB - The mammalian gastrointestinal (GI) microbiota is highly adapted to thrive in the GI environment and performs key functions related to host nutrition, physiology, development, immunity, and behavior. Successful host-bacterial associations require chemical signaling and optimal nutrient utilization and exchange. However, this important balance can be severely disrupted by environmental stimuli, with one of the most common insults upon the microbiota being infectious diseases. Although the microbiota acts as a barrier toward enteric pathogens, many enteric pathogens exploit signals and nutrients derived from both the microbiota and host to regulate their virulence programs. Here we review several signaling and nutrient recognition systems employed by GI pathogens to regulate growth and virulence. We discuss how shifts in the microbiota composition change host susceptibility to infection and how dietary changes or manipulation of the microbiota could potentially prevent and/or ameliorate GI infections.

UR - http://www.scopus.com/inward/record.url?scp=84941284307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941284307&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2015.08.007

DO - 10.1016/j.chom.2015.08.007

M3 - Article

C2 - 26355214

AN - SCOPUS:84941284307

VL - 18

SP - 275

EP - 284

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 3

ER -