Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease

Rochelle E. Tractenberg, Anthony Gamst, Myron F. Weiner, Elisabeth Koss, Ronald G. Thomas, Linda Teri, Leon Thal

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study describes two well-characterized groups of Alzheimer's disease (AD) patients with similar levels of cognitive functioning, but with different overall behavioral disturbance levels. We sought to determine the nature of this difference - whether AD patients with higher levels of behavioral disturbance (n = 148) differ from less disturbed AD patients (n = 235) in terms of (a) the range of symptoms exhibited, (b) the frequency of occurrence of these symptoms, or (c) both of these. We defined and operationalized 'diversity of behaviors' and 'frequency' with respect to the item-level responses on the Cohen-Mansfield agitation inventory (CMAI). We found that, in these two samples of AD patients, differences occurred in the frequency of 10 out of 21 behaviors, rather than in a variety of endorsed behaviors. These 10 behaviors, observed at different frequencies in both groups, may be useful for monitoring change in studies of drugs or behavioral interventions for behavioral disturbance in persons with AD.

Original languageEnglish (US)
Pages (from-to)886-891
Number of pages6
JournalInternational Journal of Geriatric Psychiatry
Volume16
Issue number9
DOIs
StatePublished - 2001

Fingerprint

Behavioral Symptoms
Alzheimer Disease
Equipment and Supplies
Pharmaceutical Preparations

Keywords

  • Agitation
  • Alzheimer's disease
  • Assessment
  • Behavioral disturbance

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Tractenberg, R. E., Gamst, A., Weiner, M. F., Koss, E., Thomas, R. G., Teri, L., & Thal, L. (2001). Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease. International Journal of Geriatric Psychiatry, 16(9), 886-891. https://doi.org/10.1002/gps.441

Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease. / Tractenberg, Rochelle E.; Gamst, Anthony; Weiner, Myron F.; Koss, Elisabeth; Thomas, Ronald G.; Teri, Linda; Thal, Leon.

In: International Journal of Geriatric Psychiatry, Vol. 16, No. 9, 2001, p. 886-891.

Research output: Contribution to journalArticle

Tractenberg, RE, Gamst, A, Weiner, MF, Koss, E, Thomas, RG, Teri, L & Thal, L 2001, 'Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease', International Journal of Geriatric Psychiatry, vol. 16, no. 9, pp. 886-891. https://doi.org/10.1002/gps.441
Tractenberg, Rochelle E. ; Gamst, Anthony ; Weiner, Myron F. ; Koss, Elisabeth ; Thomas, Ronald G. ; Teri, Linda ; Thal, Leon. / Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease. In: International Journal of Geriatric Psychiatry. 2001 ; Vol. 16, No. 9. pp. 886-891.
@article{4383ccfc1db24b8e96c731fbe34466d2,
title = "Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease",
abstract = "This study describes two well-characterized groups of Alzheimer's disease (AD) patients with similar levels of cognitive functioning, but with different overall behavioral disturbance levels. We sought to determine the nature of this difference - whether AD patients with higher levels of behavioral disturbance (n = 148) differ from less disturbed AD patients (n = 235) in terms of (a) the range of symptoms exhibited, (b) the frequency of occurrence of these symptoms, or (c) both of these. We defined and operationalized 'diversity of behaviors' and 'frequency' with respect to the item-level responses on the Cohen-Mansfield agitation inventory (CMAI). We found that, in these two samples of AD patients, differences occurred in the frequency of 10 out of 21 behaviors, rather than in a variety of endorsed behaviors. These 10 behaviors, observed at different frequencies in both groups, may be useful for monitoring change in studies of drugs or behavioral interventions for behavioral disturbance in persons with AD.",
keywords = "Agitation, Alzheimer's disease, Assessment, Behavioral disturbance",
author = "Tractenberg, {Rochelle E.} and Anthony Gamst and Weiner, {Myron F.} and Elisabeth Koss and Thomas, {Ronald G.} and Linda Teri and Leon Thal",
year = "2001",
doi = "10.1002/gps.441",
language = "English (US)",
volume = "16",
pages = "886--891",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

TY - JOUR

T1 - Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease

AU - Tractenberg, Rochelle E.

AU - Gamst, Anthony

AU - Weiner, Myron F.

AU - Koss, Elisabeth

AU - Thomas, Ronald G.

AU - Teri, Linda

AU - Thal, Leon

PY - 2001

Y1 - 2001

N2 - This study describes two well-characterized groups of Alzheimer's disease (AD) patients with similar levels of cognitive functioning, but with different overall behavioral disturbance levels. We sought to determine the nature of this difference - whether AD patients with higher levels of behavioral disturbance (n = 148) differ from less disturbed AD patients (n = 235) in terms of (a) the range of symptoms exhibited, (b) the frequency of occurrence of these symptoms, or (c) both of these. We defined and operationalized 'diversity of behaviors' and 'frequency' with respect to the item-level responses on the Cohen-Mansfield agitation inventory (CMAI). We found that, in these two samples of AD patients, differences occurred in the frequency of 10 out of 21 behaviors, rather than in a variety of endorsed behaviors. These 10 behaviors, observed at different frequencies in both groups, may be useful for monitoring change in studies of drugs or behavioral interventions for behavioral disturbance in persons with AD.

AB - This study describes two well-characterized groups of Alzheimer's disease (AD) patients with similar levels of cognitive functioning, but with different overall behavioral disturbance levels. We sought to determine the nature of this difference - whether AD patients with higher levels of behavioral disturbance (n = 148) differ from less disturbed AD patients (n = 235) in terms of (a) the range of symptoms exhibited, (b) the frequency of occurrence of these symptoms, or (c) both of these. We defined and operationalized 'diversity of behaviors' and 'frequency' with respect to the item-level responses on the Cohen-Mansfield agitation inventory (CMAI). We found that, in these two samples of AD patients, differences occurred in the frequency of 10 out of 21 behaviors, rather than in a variety of endorsed behaviors. These 10 behaviors, observed at different frequencies in both groups, may be useful for monitoring change in studies of drugs or behavioral interventions for behavioral disturbance in persons with AD.

KW - Agitation

KW - Alzheimer's disease

KW - Assessment

KW - Behavioral disturbance

UR - http://www.scopus.com/inward/record.url?scp=0034808834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034808834&partnerID=8YFLogxK

U2 - 10.1002/gps.441

DO - 10.1002/gps.441

M3 - Article

C2 - 11571769

AN - SCOPUS:0034808834

VL - 16

SP - 886

EP - 891

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 9

ER -