Frequency Offset Corrected Inversion Pulse for B0 and B1 Insensitive Fat Suppression at 3T: Application to MR Neurography of Brachial Plexus

Xinzeng Wang, Joshua S. Greer, Ivan E. Dimitrov, Parham Pezeshk, Avneesh Chhabra, Ananth J. Madhuranthakam

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The 3D short tau inversion recovery (STIR) sequence is routinely used in clinical MRI to achieve robust fat suppression. However, the performance of the commonly used adiabatic inversion pulse, hyperbolic secant (HS), is compromised in challenging areas with increased B0 and B1 inhomogeneities, such as brachial plexus at 3T. Purpose: To demonstrate the frequency offset corrected inversion (FOCI) pulse as an efficient fat suppression STIR pulse with increased robustness to B0 and B1 inhomogeneities at 3T, compared to the HS pulse. Study Type: Prospective. Subjects/Phantom: Initial evaluation was performed in phantoms and one healthy volunteer by varying the B1 field, while subsequent comparison was performed in three healthy volunteers and five patients without varying the B1. Field Strength/Sequence: 3T; 3D TSE-STIR with HS and FOCI pulses. Assessment: Brachial plexus images were qualitatively evaluated by two musculoskeletal radiologists independently using a four-point grading scale for fat suppression, shading artifacts, and nerve visualization. Statistical Test: The Wilcoxon signed-rank test with P < 0.05 was considered statistically significant. Results: Simulations and phantom experiments demonstrated broader bandwidth (2.5 kHz vs. 0.83 kHz, increased B0 robustness) at the same adiabatic threshold and lower adiabatic threshold (5 μT vs. 7 μT at 3.5 ppm, increased B1 robustness) at the same bandwidth with the FOCI pulse compared to the HS pulse With increased bandwidth, the FOCI pulse achieved robust fat suppression even at 50% of maximum B1 strength, while the HS pulse required >75% of maximum B1 strength. Compared to the standard 3D TSE-STIR with HS pulse, the FOCI pulse achieved uniform fat suppression (P < 0.05), better nerve visualization (P < 0.05), and minimal shading artifacts (P < 0.01) in brachial plexus at 3T. Data Conclusion: The FOCI pulse has increased robustness to B0 and B1 inhomogeneities, compared to the HS pulse, and enables uniform fat suppression in brachial plexus at 3T. Level of Evidence: 1. Techinical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;48:1104–1111.

Original languageEnglish (US)
Pages (from-to)1104-1111
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume48
Issue number4
DOIs
StatePublished - Oct 1 2018

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Brachial Plexus
Fats
Artifacts
Healthy Volunteers
Sequence Inversion
Nonparametric Statistics
Prospective Studies

Keywords

  • 3D neurography
  • brachial plexus
  • fat suppression
  • FOCI
  • peripheral nerves
  • STIR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{648ed0fdffb94877b94ed1c19af75be3,
title = "Frequency Offset Corrected Inversion Pulse for B0 and B1 Insensitive Fat Suppression at 3T: Application to MR Neurography of Brachial Plexus",
abstract = "Background: The 3D short tau inversion recovery (STIR) sequence is routinely used in clinical MRI to achieve robust fat suppression. However, the performance of the commonly used adiabatic inversion pulse, hyperbolic secant (HS), is compromised in challenging areas with increased B0 and B1 inhomogeneities, such as brachial plexus at 3T. Purpose: To demonstrate the frequency offset corrected inversion (FOCI) pulse as an efficient fat suppression STIR pulse with increased robustness to B0 and B1 inhomogeneities at 3T, compared to the HS pulse. Study Type: Prospective. Subjects/Phantom: Initial evaluation was performed in phantoms and one healthy volunteer by varying the B1 field, while subsequent comparison was performed in three healthy volunteers and five patients without varying the B1. Field Strength/Sequence: 3T; 3D TSE-STIR with HS and FOCI pulses. Assessment: Brachial plexus images were qualitatively evaluated by two musculoskeletal radiologists independently using a four-point grading scale for fat suppression, shading artifacts, and nerve visualization. Statistical Test: The Wilcoxon signed-rank test with P < 0.05 was considered statistically significant. Results: Simulations and phantom experiments demonstrated broader bandwidth (2.5 kHz vs. 0.83 kHz, increased B0 robustness) at the same adiabatic threshold and lower adiabatic threshold (5 μT vs. 7 μT at 3.5 ppm, increased B1 robustness) at the same bandwidth with the FOCI pulse compared to the HS pulse With increased bandwidth, the FOCI pulse achieved robust fat suppression even at 50{\%} of maximum B1 strength, while the HS pulse required >75{\%} of maximum B1 strength. Compared to the standard 3D TSE-STIR with HS pulse, the FOCI pulse achieved uniform fat suppression (P < 0.05), better nerve visualization (P < 0.05), and minimal shading artifacts (P < 0.01) in brachial plexus at 3T. Data Conclusion: The FOCI pulse has increased robustness to B0 and B1 inhomogeneities, compared to the HS pulse, and enables uniform fat suppression in brachial plexus at 3T. Level of Evidence: 1. Techinical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;48:1104–1111.",
keywords = "3D neurography, brachial plexus, fat suppression, FOCI, peripheral nerves, STIR",
author = "Xinzeng Wang and Greer, {Joshua S.} and Dimitrov, {Ivan E.} and Parham Pezeshk and Avneesh Chhabra and Madhuranthakam, {Ananth J.}",
year = "2018",
month = "10",
day = "1",
doi = "10.1002/jmri.26021",
language = "English (US)",
volume = "48",
pages = "1104--1111",
journal = "Journal of Magnetic Resonance Imaging",
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TY - JOUR

T1 - Frequency Offset Corrected Inversion Pulse for B0 and B1 Insensitive Fat Suppression at 3T

T2 - Application to MR Neurography of Brachial Plexus

AU - Wang, Xinzeng

AU - Greer, Joshua S.

AU - Dimitrov, Ivan E.

AU - Pezeshk, Parham

AU - Chhabra, Avneesh

AU - Madhuranthakam, Ananth J.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: The 3D short tau inversion recovery (STIR) sequence is routinely used in clinical MRI to achieve robust fat suppression. However, the performance of the commonly used adiabatic inversion pulse, hyperbolic secant (HS), is compromised in challenging areas with increased B0 and B1 inhomogeneities, such as brachial plexus at 3T. Purpose: To demonstrate the frequency offset corrected inversion (FOCI) pulse as an efficient fat suppression STIR pulse with increased robustness to B0 and B1 inhomogeneities at 3T, compared to the HS pulse. Study Type: Prospective. Subjects/Phantom: Initial evaluation was performed in phantoms and one healthy volunteer by varying the B1 field, while subsequent comparison was performed in three healthy volunteers and five patients without varying the B1. Field Strength/Sequence: 3T; 3D TSE-STIR with HS and FOCI pulses. Assessment: Brachial plexus images were qualitatively evaluated by two musculoskeletal radiologists independently using a four-point grading scale for fat suppression, shading artifacts, and nerve visualization. Statistical Test: The Wilcoxon signed-rank test with P < 0.05 was considered statistically significant. Results: Simulations and phantom experiments demonstrated broader bandwidth (2.5 kHz vs. 0.83 kHz, increased B0 robustness) at the same adiabatic threshold and lower adiabatic threshold (5 μT vs. 7 μT at 3.5 ppm, increased B1 robustness) at the same bandwidth with the FOCI pulse compared to the HS pulse With increased bandwidth, the FOCI pulse achieved robust fat suppression even at 50% of maximum B1 strength, while the HS pulse required >75% of maximum B1 strength. Compared to the standard 3D TSE-STIR with HS pulse, the FOCI pulse achieved uniform fat suppression (P < 0.05), better nerve visualization (P < 0.05), and minimal shading artifacts (P < 0.01) in brachial plexus at 3T. Data Conclusion: The FOCI pulse has increased robustness to B0 and B1 inhomogeneities, compared to the HS pulse, and enables uniform fat suppression in brachial plexus at 3T. Level of Evidence: 1. Techinical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;48:1104–1111.

AB - Background: The 3D short tau inversion recovery (STIR) sequence is routinely used in clinical MRI to achieve robust fat suppression. However, the performance of the commonly used adiabatic inversion pulse, hyperbolic secant (HS), is compromised in challenging areas with increased B0 and B1 inhomogeneities, such as brachial plexus at 3T. Purpose: To demonstrate the frequency offset corrected inversion (FOCI) pulse as an efficient fat suppression STIR pulse with increased robustness to B0 and B1 inhomogeneities at 3T, compared to the HS pulse. Study Type: Prospective. Subjects/Phantom: Initial evaluation was performed in phantoms and one healthy volunteer by varying the B1 field, while subsequent comparison was performed in three healthy volunteers and five patients without varying the B1. Field Strength/Sequence: 3T; 3D TSE-STIR with HS and FOCI pulses. Assessment: Brachial plexus images were qualitatively evaluated by two musculoskeletal radiologists independently using a four-point grading scale for fat suppression, shading artifacts, and nerve visualization. Statistical Test: The Wilcoxon signed-rank test with P < 0.05 was considered statistically significant. Results: Simulations and phantom experiments demonstrated broader bandwidth (2.5 kHz vs. 0.83 kHz, increased B0 robustness) at the same adiabatic threshold and lower adiabatic threshold (5 μT vs. 7 μT at 3.5 ppm, increased B1 robustness) at the same bandwidth with the FOCI pulse compared to the HS pulse With increased bandwidth, the FOCI pulse achieved robust fat suppression even at 50% of maximum B1 strength, while the HS pulse required >75% of maximum B1 strength. Compared to the standard 3D TSE-STIR with HS pulse, the FOCI pulse achieved uniform fat suppression (P < 0.05), better nerve visualization (P < 0.05), and minimal shading artifacts (P < 0.01) in brachial plexus at 3T. Data Conclusion: The FOCI pulse has increased robustness to B0 and B1 inhomogeneities, compared to the HS pulse, and enables uniform fat suppression in brachial plexus at 3T. Level of Evidence: 1. Techinical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;48:1104–1111.

KW - 3D neurography

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KW - FOCI

KW - peripheral nerves

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