From legumes to leukocytes

Biological roles for sulfated carbohydrates

Lora V. Hooper, Stephen M. Manzella, Jacques U. Baenziger

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Carbohydrates attached to proteins and lipids characteristically display complex and heterogeneous structures. However, it is becoming increasingly clear that carbohydrates with definite biological functions also exhibit unique structural features. A number of glycoproteins and glycolipids have been shown to bear oligosaccharides containing sulfate. Often, addition of a sulfate moiety turns a relatively common structural motif into a unique carbohydrate with the potential to be recognized by a specific receptor or lectin. This is clearly the case in three systems in which sulfated oligosaccharides have been shown to play a well-defined biological role: 1) control of the circulatory half-life of luteinizing hormone, 2) symbiotic interactions between leguminous plants and nitrogen-fixing bacteria, and 3) homing of lymphocytes to lymph nodes. The rapidly growing list of glycoproteins and glycolipids identified as bearing sulfated oligosaccharides suggests that sulfated carbohydrates play important biological roles in numerous other systems as well.

Original languageEnglish (US)
Pages (from-to)1137-1146
Number of pages10
JournalFASEB Journal
Volume10
Issue number10
StatePublished - 1996

Fingerprint

Fabaceae
leukocytes
Leukocytes
legumes
Oligosaccharides
Carbohydrates
oligosaccharides
carbohydrates
glycolipids
Glycolipids
Sulfates
glycoproteins
Glycoproteins
sulfates
Bearings (structural)
Mitogen Receptors
nitrogen-fixing bacteria
Lymphocytes
luteinizing hormone
Luteinizing Hormone

Keywords

  • glycoprotein
  • luteinizing hormone
  • nod factor
  • selectin
  • sulfotranferase

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Hooper, L. V., Manzella, S. M., & Baenziger, J. U. (1996). From legumes to leukocytes: Biological roles for sulfated carbohydrates. FASEB Journal, 10(10), 1137-1146.

From legumes to leukocytes : Biological roles for sulfated carbohydrates. / Hooper, Lora V.; Manzella, Stephen M.; Baenziger, Jacques U.

In: FASEB Journal, Vol. 10, No. 10, 1996, p. 1137-1146.

Research output: Contribution to journalArticle

Hooper, LV, Manzella, SM & Baenziger, JU 1996, 'From legumes to leukocytes: Biological roles for sulfated carbohydrates', FASEB Journal, vol. 10, no. 10, pp. 1137-1146.
Hooper, Lora V. ; Manzella, Stephen M. ; Baenziger, Jacques U. / From legumes to leukocytes : Biological roles for sulfated carbohydrates. In: FASEB Journal. 1996 ; Vol. 10, No. 10. pp. 1137-1146.
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