TY - JOUR
T1 - From lipid secretion to cholesterol crystallization in bile. Relevance in cholesterol gallstone disease.
AU - Portincasa, Piero
AU - Moschetta, Antonio
AU - Palasciano, Giuseppe
PY - 2002
Y1 - 2002
N2 - Failure of cholesterol homeostasis in the body can lead to cholesterol gallstone disease, the most common and costly gastrointestinal disease. The primum movens in cholesterol gallstone formation is the hypersecretion of hepatic cholesterol; this condition leads to bile chronically supersaturated with cholesterol which is prone to rapid precipitation as cholesterol crystals in the gallbladder. Essential topics reviewed here deal with pathways of biliary lipid secretion, cholesterol solubilization and crystallization in bile, according to recent advances. Main in vivo events in cholesterol gallstone disease are also described.
AB - Failure of cholesterol homeostasis in the body can lead to cholesterol gallstone disease, the most common and costly gastrointestinal disease. The primum movens in cholesterol gallstone formation is the hypersecretion of hepatic cholesterol; this condition leads to bile chronically supersaturated with cholesterol which is prone to rapid precipitation as cholesterol crystals in the gallbladder. Essential topics reviewed here deal with pathways of biliary lipid secretion, cholesterol solubilization and crystallization in bile, according to recent advances. Main in vivo events in cholesterol gallstone disease are also described.
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U2 - 10.1016/s1665-2681(19)32170-2
DO - 10.1016/s1665-2681(19)32170-2
M3 - Review article
C2 - 15280810
AN - SCOPUS:4344581065
SN - 1665-2681
VL - 1
SP - 121
EP - 128
JO - Annals of hepatology : official journal of the Mexican Association of Hepatology
JF - Annals of hepatology : official journal of the Mexican Association of Hepatology
IS - 3
ER -