From mice and men to earth and space: Joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation

Jerry W. Shay, Francis A. Cucinotta, Frank M. Sulzman, C. Norman Coleman, John D. Minna

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

On June 27-28, 2011, scientists from the National Cancer Institute (NCI), NASA, and academia met in Bethesda to discuss major lung cancer issues confronting each organization. For NASA, available data suggest that lung cancer is the largest potential cancer risk from space travel for both men and women and quantitative risk assessment information for mission planning is needed. In space, the radiation risk is from high energy and charge (HZE) nuclei (such as Fe) and high-energy protons from solar flares and not from gamma radiation. In contrast, the NCI is endeavoring to estimate the increased lung cancer risk from the potential widespread implementation of computed tomographic (CT) screening in individuals at high risk for developing lung cancer based on the National Lung Cancer Screening Trial (NLST). For the latter, exposure will be X-rays from CT scans from the screening (which uses "low-dose" CT scans) and also from follow-up scans used to evaluate abnormalities found during initial screening. Topics discussed included the risk of lung cancer arising after HZE particle, proton, and low-dose exposure to Earth's radiation. The workshop examined preclinical models, epidemiology, molecular markers, "omics" technology, radiobiology issues, and lung stem cells that relate to the development of lung cancer.

Original languageEnglish (US)
Pages (from-to)6926-6929
Number of pages4
JournalCancer Research
Volume71
Issue number22
DOIs
StatePublished - Nov 15 2011

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United States National Aeronautics and Space Administration
National Cancer Institute (U.S.)
Lung Neoplasms
Joints
Radiation
Education
Protons
Cosmic Radiation
Solar Activity
Radiobiology
Molecular Models
Molecular Epidemiology
Gamma Rays
Early Detection of Cancer
Stem Cells
X-Rays
Organizations
Technology
Lung

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

From mice and men to earth and space : Joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation. / Shay, Jerry W.; Cucinotta, Francis A.; Sulzman, Frank M.; Coleman, C. Norman; Minna, John D.

In: Cancer Research, Vol. 71, No. 22, 15.11.2011, p. 6926-6929.

Research output: Contribution to journalArticle

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