From observation to experimentation

Leptin action in the mediobasal hypothalamus

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The burgeoning obesity epidemic has fueled the drive to describe, mechanistically, metabolic homeostasis. From the early theories implicating glucose as a principal modulator grew an understanding of a complex array of metabolic signals, sensed by peripheral organs along with specific locations within the central nervous system (CNS). The discovery that leptin, an adipose-derived hormone, acts within the mediobasal hypothalamus to control food intake and energy expenditure ushered in a decade of research that went on to describe not only the specific nuclei and cell type, such as proopiomelanocortin neurons of the arcuate nucleus, that respond to leptin but also the signaling cascades that mediated its effects. This review thus highlights the sites and mechanisms of action of leptin, both in the hypothalamus and in extrahypothalamic sites within the CNS, and shows our current knowledge and direction of future research aimed at understanding the multifunctional role of leptin in maintaining metabolic homeostasis.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume89
Issue number3
DOIs
StatePublished - Mar 1 2009

Fingerprint

Leptin
Hypothalamus
Observation
Homeostasis
Central Nervous System
Pro-Opiomelanocortin
Arcuate Nucleus of Hypothalamus
Cell Nucleus
Energy Metabolism
Obesity
Eating
Hormones
Neurons
Glucose
Research

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

From observation to experimentation : Leptin action in the mediobasal hypothalamus. / Williams, Kevin W.; Scott, Michael M.; Elmquist, Joel K.

In: American Journal of Clinical Nutrition, Vol. 89, No. 3, 01.03.2009.

Research output: Contribution to journalArticle

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