From progenitors to differentiated cells in the vertebrate retina

Michalis Agathocleous, William A. Harris

Research output: Contribution to journalReview article

155 Scopus citations

Abstract

Multipotent retinal progenitors undergo a varied number of divisions to produce clones of heterogeneous sizes and cell types. We describe the transition from a proliferating progenitor to a differentiated postmitotic cell and discuss how controls of proliferation operate within individual cells as well as in the whole tissue. We discuss how extracellular and intracellular signaling, transcriptional regulation, cell cycle kinetics, interkinetic nuclear migration, orientation of cell division, and epigenetic modifications all interact to regulate a progenitor's transition from division to differentiation. We also propose some directions for future research.

Original languageEnglish (US)
Pages (from-to)45-69
Number of pages25
JournalAnnual Review of Cell and Developmental Biology
Volume25
DOIs
Publication statusPublished - Nov 1 2009

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Keywords

  • Ciliary margin
  • Lineage
  • Müller glia
  • Neuron
  • Stem cell

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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