Abstract
Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead transcriptional regulators. Here we demonstrate how to identify FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications.
Original language | English (US) |
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Pages (from-to) | 209-215 |
Number of pages | 7 |
Journal | Mechanisms of Ageing and Development |
Volume | 126 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2005 |
Externally published | Yes |
Keywords
- Aging
- Comparative genomics
- Foxo target genes
- Insulin pathway
ASJC Scopus subject areas
- Aging
- Developmental Biology