From worm to human: Bioinformatics approaches to identify FOXO target genes

Zhenyu Xuan, Michael Q. Zhang

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead transcriptional regulators. Here we demonstrate how to identify FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalMechanisms of Ageing and Development
Volume126
Issue number1
DOIs
StatePublished - Jan 1 2005

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Keywords

  • Aging
  • Comparative genomics
  • Foxo target genes
  • Insulin pathway

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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