Fulminant Epstein-Barr viral hepatitis

Orthotopic liver transplantation and review of the literature

A. P. Feranchak, R. W. Tyson, M. R. Narkewicz, F. M. Karrer, R. J. Sokol

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Acute hepatic failure caused by primary Epstein-Barr virus (EBV) infection has been reported in the literature in 16 cases, with an overall mortality of 87%. We report a case of fulminant hepatic failure in an immunocompetent young girl caused by primary EBV infection that was treated by orthotopic liver transplantation. After transplantation she has been treated with low-dose immuno-suppression, a pooled gammaglobulin preparation containing anti-EBV antibodies, and anti-viral therapy. The patient is presently doing well 2 years after transplantation without evidence of clinical EBV infection, primary immunodeficiency, or lymphoproliferative disease.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalLiver Transplantation and Surgery
Volume4
Issue number6
StatePublished - 1998

Fingerprint

Epstein-Barr Virus Infections
Liver Transplantation
Hepatitis
Acute Liver Failure
Transplantation
Viral Antibodies
Human Herpesvirus 4
Anti-Idiotypic Antibodies
Mortality
Therapeutics

ASJC Scopus subject areas

  • Hepatology
  • Surgery

Cite this

Fulminant Epstein-Barr viral hepatitis : Orthotopic liver transplantation and review of the literature. / Feranchak, A. P.; Tyson, R. W.; Narkewicz, M. R.; Karrer, F. M.; Sokol, R. J.

In: Liver Transplantation and Surgery, Vol. 4, No. 6, 1998, p. 469-476.

Research output: Contribution to journalArticle

Feranchak, A. P. ; Tyson, R. W. ; Narkewicz, M. R. ; Karrer, F. M. ; Sokol, R. J. / Fulminant Epstein-Barr viral hepatitis : Orthotopic liver transplantation and review of the literature. In: Liver Transplantation and Surgery. 1998 ; Vol. 4, No. 6. pp. 469-476.
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