Fulminant Epstein-Barr viral hepatitis: Orthotopic liver transplantation and review of the literature

A. P. Feranchak, R. W. Tyson, M. R. Narkewicz, F. M. Karrer, R. J. Sokol

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Acute hepatic failure caused by primary Epstein-Barr virus (EBV) infection has been reported in the literature in 16 cases, with an overall mortality of 87%. We report a case of fulminant hepatic failure in an immunocompetent young girl caused by primary EBV infection that was treated by orthotopic liver transplantation. After transplantation she has been treated with low-dose immuno-suppression, a pooled gammaglobulin preparation containing anti-EBV antibodies, and anti-viral therapy. The patient is presently doing well 2 years after transplantation without evidence of clinical EBV infection, primary immunodeficiency, or lymphoproliferative disease.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalLiver Transplantation and Surgery
Volume4
Issue number6
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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