Function of the Yersinia effector YopJ

Research output: Contribution to journalReview articlepeer-review

156 Scopus citations


The Yersinia virulence factor YopJ inhibits the host immune response and induces apoptosis by blocking multiple signaling pathways, including the MAPK and NFKB pathways in the infected cell. YopJ is a cysteine protease that cleaves a reversible post-translational modification in the form of ubiquitin or a ubiquitin-like protein. Homologues of YopJ are expressed in animal and plant pathogens, as well as a plant symbiont, suggesting a universal mechanism of regulating or modulating a variety of signaling pathways. The ability of YopJ to block the innate immune response, its activity as a ubiquitin-like protein protease and its activity with respect to mammalian signalling pathways are discussed in this review.

Original languageEnglish (US)
Pages (from-to)38-43
Number of pages6
JournalCurrent Opinion in Microbiology
Issue number1
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Function of the Yersinia effector YopJ'. Together they form a unique fingerprint.

Cite this