Function of the Yersinia effector YopJ

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

The Yersinia virulence factor YopJ inhibits the host immune response and induces apoptosis by blocking multiple signaling pathways, including the MAPK and NFKB pathways in the infected cell. YopJ is a cysteine protease that cleaves a reversible post-translational modification in the form of ubiquitin or a ubiquitin-like protein. Homologues of YopJ are expressed in animal and plant pathogens, as well as a plant symbiont, suggesting a universal mechanism of regulating or modulating a variety of signaling pathways. The ability of YopJ to block the innate immune response, its activity as a ubiquitin-like protein protease and its activity with respect to mammalian signalling pathways are discussed in this review.

Original languageEnglish (US)
Pages (from-to)38-43
Number of pages6
JournalCurrent Opinion in Microbiology
Volume5
Issue number1
DOIs
StatePublished - 2002

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Ubiquitins
Yersinia
Cysteine Proteases
Virulence Factors
Post Translational Protein Processing
Ubiquitin
Innate Immunity
Peptide Hydrolases
Apoptosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

Cite this

Function of the Yersinia effector YopJ. / Orth, Kim.

In: Current Opinion in Microbiology, Vol. 5, No. 1, 2002, p. 38-43.

Research output: Contribution to journalArticle

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