Functional activation during an auditory comprehension task in patients with temporal lobe lesions

D. C. Alsop; J. A. Detre; M. D'Esposito; R. S. Howard; Joseph A Maldjian; M. Grossman; J. Listerud; E. S. Flamm; K. D. Judy; S. W. Atlas

doi:10.1006/nimg.1996.0028

Functional activation during an auditory comprehension task in patients with temporal lobe lesions

D. C. Alsop, J. A. Detre, M. D'Esposito, R. S. Howard, Joseph A Maldjian, M. Grossman, J. Listerud, E. S. Flamm, K. D. Judy, S. W. Atlas

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) was used to map regional brain activation during an auditory comprehension task in two normal controls and two patients with left temporal lobe lesions. Activity in the superior temporal and angular gyrus regions was detected in all normal subjects. In the patients, the spatial distribution of activation ipsilateral to the lesions differed from the pattern observed in contralateral cortex or in control subjects. These studies highlight the potential of fMRI for mapping abnormal functional anatomy in the human brain.

Original language	English (US)
Pages (from-to)	55-59
Number of pages	5
Journal	NeuroImage
Volume	4
Issue number	1
DOIs	https://doi.org/10.1006/nimg.1996.0028
State	Published - Aug 1996

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

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10.1006/nimg.1996.0028

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title = "Functional activation during an auditory comprehension task in patients with temporal lobe lesions",

abstract = "Functional magnetic resonance imaging (fMRI) was used to map regional brain activation during an auditory comprehension task in two normal controls and two patients with left temporal lobe lesions. Activity in the superior temporal and angular gyrus regions was detected in all normal subjects. In the patients, the spatial distribution of activation ipsilateral to the lesions differed from the pattern observed in contralateral cortex or in control subjects. These studies highlight the potential of fMRI for mapping abnormal functional anatomy in the human brain.",

author = "Alsop, {D. C.} and Detre, {J. A.} and M. D'Esposito and Howard, {R. S.} and Maldjian, {Joseph A} and M. Grossman and J. Listerud and Flamm, {E. S.} and Judy, {K. D.} and Atlas, {S. W.}",

note = "Funding Information: This work was supported by NS01668 (to J.A.D.), NS01762 (to M.D.), and DC00039 (to M.G.) and by grants from the McDonnell– Pew Program in Cognitive Neuroscience, the Charles A. Dana Foundation, the McCabe Fund, and the University of Pennsylvania Research Foundation.",

year = "1996",

month = aug,

doi = "10.1006/nimg.1996.0028",

language = "English (US)",

volume = "4",

pages = "55--59",

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T1 - Functional activation during an auditory comprehension task in patients with temporal lobe lesions

AU - Alsop, D. C.

AU - Detre, J. A.

AU - D'Esposito, M.

AU - Howard, R. S.

AU - Maldjian, Joseph A

AU - Grossman, M.

AU - Listerud, J.

AU - Flamm, E. S.

AU - Judy, K. D.

AU - Atlas, S. W.

N1 - Funding Information: This work was supported by NS01668 (to J.A.D.), NS01762 (to M.D.), and DC00039 (to M.G.) and by grants from the McDonnell– Pew Program in Cognitive Neuroscience, the Charles A. Dana Foundation, the McCabe Fund, and the University of Pennsylvania Research Foundation.

PY - 1996/8

Y1 - 1996/8

N2 - Functional magnetic resonance imaging (fMRI) was used to map regional brain activation during an auditory comprehension task in two normal controls and two patients with left temporal lobe lesions. Activity in the superior temporal and angular gyrus regions was detected in all normal subjects. In the patients, the spatial distribution of activation ipsilateral to the lesions differed from the pattern observed in contralateral cortex or in control subjects. These studies highlight the potential of fMRI for mapping abnormal functional anatomy in the human brain.

AB - Functional magnetic resonance imaging (fMRI) was used to map regional brain activation during an auditory comprehension task in two normal controls and two patients with left temporal lobe lesions. Activity in the superior temporal and angular gyrus regions was detected in all normal subjects. In the patients, the spatial distribution of activation ipsilateral to the lesions differed from the pattern observed in contralateral cortex or in control subjects. These studies highlight the potential of fMRI for mapping abnormal functional anatomy in the human brain.

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Functional activation during an auditory comprehension task in patients with temporal lobe lesions

Abstract

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