Functional and structural comparison of PXR and CAR

John T. Moore, Linda B. Moore, Jodi M. Maglich, Steve A. Kliewer

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The nuclear receptors pregnane X receptor (PXR, NR1I2) and constitutive active receptor (CAR, NR1I3) have both been proposed to function as xenosensors, but the details of their respective physiological roles are still being elucidated. We have contrasted these two receptors in a variety of experiments including gene expression assays, cell-based ligand profiling assays, and crystallographic/structural modeling analyses. These data highlight key differences between PXR and CAR.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalBiochimica et Biophysica Acta - General Subjects
Volume1619
Issue number3
DOIs
StatePublished - Feb 17 2003

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Cytoplasmic and Nuclear Receptors
Assays
Ligands
Gene Expression
Gene expression
Experiments
pregnane X receptor
constitutive androstane receptor

Keywords

  • Constitutive active receptor (CAR)
  • Nuclear receptor
  • Pregnane X receptor (PXR)
  • Xenobiotic metabolism

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Functional and structural comparison of PXR and CAR. / Moore, John T.; Moore, Linda B.; Maglich, Jodi M.; Kliewer, Steve A.

In: Biochimica et Biophysica Acta - General Subjects, Vol. 1619, No. 3, 17.02.2003, p. 235-238.

Research output: Contribution to journalArticle

Moore, John T. ; Moore, Linda B. ; Maglich, Jodi M. ; Kliewer, Steve A. / Functional and structural comparison of PXR and CAR. In: Biochimica et Biophysica Acta - General Subjects. 2003 ; Vol. 1619, No. 3. pp. 235-238.
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