Functional identification of neural genes

Lawrence H. Pinto, Joseph S Takahashi

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Genetic dissection is the use of a series of mutations that affect a biological process in order to identify the functional elements of the process; 1 this permits elucidation of their function and interactions. 2 Genetic dissection has been used routinely to study biochemical pathways. A series of single gene mutations, affecting enzymes within a particular pathway, can each perturb the product of the pathway, e.g., by reducing the function of the essential enzymes. Each affected enzyme can then be identified biochemically by taking advantage of knowledge of the substrates and products in the pathway.

Original languageEnglish (US)
Title of host publicationMethods in Genomic Neuroscience
PublisherCRC Press
Pages65-90
Number of pages26
ISBN (Electronic)9781420038477
ISBN (Print)0849323975, 9780849323973
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Pinto, L. H., & Takahashi, J. S. (2001). Functional identification of neural genes. In Methods in Genomic Neuroscience (pp. 65-90). CRC Press.