Functional Magnetic Resonance Imaging in Partial Epilepsy

G. L. Morris; W. M. Mueller; F. Z. Yetkin; V. M. Haughton; T. A. Hammeke; S. Swanson; S. M. Rao; A. Jesmanowicz; L. D. Estkowski; P. A. Bandettini; E. C. Wong; J. S. Hyde

doi:10.1111/j.1528-1157.1994.tb01788.x

Functional Magnetic Resonance Imaging in Partial Epilepsy

G. L. Morris, W. M. Mueller, F. Z. Yetkin, V. M. Haughton, T. A. Hammeke, S. Swanson, S. M. Rao, A. Jesmanowicz, L. D. Estkowski, P. A. Bandettini, E. C. Wong, J. S. Hyde

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Summary: Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. The model used to explain the changes in signal linked temporally with cerebral activity is a reduction in cerebral capillary deoxyhemoglobin concentration due to the increased blood flow that accompanies neuronal activity in the cerebrum. FMRI has been used in normal subjects but not extensively in patients. To determine the feasibility of using FMRI to map cerebral functions in patients with partial epilepsy syndromes, we performed a pilot study, using FMRI to identify signal changes in motor and language areas in response to tasks that activate those areas. Signal changes in epilepsy patients approximated those observed in volunteers. We conclude that FMRI can be developed as a method for functional cerebral mapping in partial epilepsies.

Original language	English (US)
Pages (from-to)	1194-1198
Number of pages	5
Journal	Epilepsia
Volume	35
Issue number	6
DOIs	https://doi.org/10.1111/j.1528-1157.1994.tb01788.x
State	Published - Nov 1994

Keywords

Deoxyhemoglobin
Epilepsy surgery
Functional magnetic resonance imaging
Functional mapping
Neuronal activity
Partial epilepsy
Regional cerebral blood flow

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1528-1157.1994.tb01788.x

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title = "Functional Magnetic Resonance Imaging in Partial Epilepsy",

abstract = "Summary: Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. The model used to explain the changes in signal linked temporally with cerebral activity is a reduction in cerebral capillary deoxyhemoglobin concentration due to the increased blood flow that accompanies neuronal activity in the cerebrum. FMRI has been used in normal subjects but not extensively in patients. To determine the feasibility of using FMRI to map cerebral functions in patients with partial epilepsy syndromes, we performed a pilot study, using FMRI to identify signal changes in motor and language areas in response to tasks that activate those areas. Signal changes in epilepsy patients approximated those observed in volunteers. We conclude that FMRI can be developed as a method for functional cerebral mapping in partial epilepsies.",

keywords = "Deoxyhemoglobin, Epilepsy surgery, Functional magnetic resonance imaging, Functional mapping, Neuronal activity, Partial epilepsy, Regional cerebral blood flow",

author = "Morris, {G. L.} and Mueller, {W. M.} and Yetkin, {F. Z.} and Haughton, {V. M.} and Hammeke, {T. A.} and S. Swanson and Rao, {S. M.} and A. Jesmanowicz and Estkowski, {L. D.} and Bandettini, {P. A.} and Wong, {E. C.} and Hyde, {J. S.}",

year = "1994",

month = nov,

doi = "10.1111/j.1528-1157.1994.tb01788.x",

language = "English (US)",

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AU - Morris, G. L.

AU - Mueller, W. M.

AU - Yetkin, F. Z.

AU - Haughton, V. M.

AU - Hammeke, T. A.

AU - Swanson, S.

AU - Rao, S. M.

AU - Jesmanowicz, A.

AU - Estkowski, L. D.

AU - Bandettini, P. A.

AU - Wong, E. C.

AU - Hyde, J. S.

PY - 1994/11

Y1 - 1994/11

N2 - Summary: Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. The model used to explain the changes in signal linked temporally with cerebral activity is a reduction in cerebral capillary deoxyhemoglobin concentration due to the increased blood flow that accompanies neuronal activity in the cerebrum. FMRI has been used in normal subjects but not extensively in patients. To determine the feasibility of using FMRI to map cerebral functions in patients with partial epilepsy syndromes, we performed a pilot study, using FMRI to identify signal changes in motor and language areas in response to tasks that activate those areas. Signal changes in epilepsy patients approximated those observed in volunteers. We conclude that FMRI can be developed as a method for functional cerebral mapping in partial epilepsies.

AB - Summary: Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. The model used to explain the changes in signal linked temporally with cerebral activity is a reduction in cerebral capillary deoxyhemoglobin concentration due to the increased blood flow that accompanies neuronal activity in the cerebrum. FMRI has been used in normal subjects but not extensively in patients. To determine the feasibility of using FMRI to map cerebral functions in patients with partial epilepsy syndromes, we performed a pilot study, using FMRI to identify signal changes in motor and language areas in response to tasks that activate those areas. Signal changes in epilepsy patients approximated those observed in volunteers. We conclude that FMRI can be developed as a method for functional cerebral mapping in partial epilepsies.

KW - Deoxyhemoglobin

KW - Epilepsy surgery

KW - Functional magnetic resonance imaging

KW - Functional mapping

KW - Neuronal activity

KW - Partial epilepsy

KW - Regional cerebral blood flow

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Functional Magnetic Resonance Imaging in Partial Epilepsy

Abstract

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ASJC Scopus subject areas

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