Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors

Wade M. Mueller, F. Zerrin Yetkin, Thomas A. Hammeke, George L. Morris, Sara J. Swanson, Kenneth Reichert, Robert Cox, Victor M. Haughton

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to determine the usefulness of functional magnetic resonance imaging (FMRI) to map cerebral functions in patients with frontal or parietal tumors. METHODS: Charts and images of patients with cerebral tumors or vascular malformations who underwent FMRI with an echoplanar technique were reviewed. The FMRI maps of motor (11 patients), tactile sensory (12 patients), and language tasks (4 patients) were obtained. The location of the FMRI activation and the positive responses to intraoperative cortical stimulation were compared. The reliability of the paradigms for mapping the rolandic cortex was evaluated. RESULTS: Rolandic cortex was activated by tactile tasks in all 12 patients and by motor tasks in 10 of 11 patients. Language tasks elicited activation in each of the four patients. Activation was obtained within edematous brain and adjacent to tumors. FMRI in three cases with intraoperative electrocortical mapping results showed activation for a language, tactile, or motor task within the same gyrus in which stimulation elicited a related motor, sensory, or language function. In patients with >2 cm between the margin of the tumor, as revealed by magnetic resonance imaging, and the activation, no decline in motor function occurred from surgical resection. CONCLUSIONS: FMRI of tactile, motor, and language tasks is feasible in patients with cerebral tumors. FMRI shows promise as a means of determining the risk of a postoperative motor deficit from surgical resection of frontal or parietal tumors.

Original languageEnglish (US)
Pages (from-to)515-521
Number of pages7
JournalNeurosurgery
Volume39
Issue number3
StatePublished - Sep 1996

Fingerprint

Motor Cortex
Magnetic Resonance Imaging
Touch
Neoplasms
Language
Vascular Malformations

Keywords

  • Brain mapping
  • Cerebral neoplasms
  • Cortical stimulation
  • Functional magnetic resonance imaging
  • Functional mapping
  • Intraoperative brain mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Mueller, W. M., Yetkin, F. Z., Hammeke, T. A., Morris, G. L., Swanson, S. J., Reichert, K., ... Haughton, V. M. (1996). Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors. Neurosurgery, 39(3), 515-521.

Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors. / Mueller, Wade M.; Yetkin, F. Zerrin; Hammeke, Thomas A.; Morris, George L.; Swanson, Sara J.; Reichert, Kenneth; Cox, Robert; Haughton, Victor M.

In: Neurosurgery, Vol. 39, No. 3, 09.1996, p. 515-521.

Research output: Contribution to journalArticle

Mueller, WM, Yetkin, FZ, Hammeke, TA, Morris, GL, Swanson, SJ, Reichert, K, Cox, R & Haughton, VM 1996, 'Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors', Neurosurgery, vol. 39, no. 3, pp. 515-521.
Mueller WM, Yetkin FZ, Hammeke TA, Morris GL, Swanson SJ, Reichert K et al. Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors. Neurosurgery. 1996 Sep;39(3):515-521.
Mueller, Wade M. ; Yetkin, F. Zerrin ; Hammeke, Thomas A. ; Morris, George L. ; Swanson, Sara J. ; Reichert, Kenneth ; Cox, Robert ; Haughton, Victor M. / Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors. In: Neurosurgery. 1996 ; Vol. 39, No. 3. pp. 515-521.
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