FUNCTIONAL SUBDIVISION OF ISLETS OF LANGERHANS AND POSSIBLE ROLE OF D CELLS

Lelio Orci, Roger H Unger

Research output: Contribution to journalArticle

296 Scopus citations

Abstract

Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet-i.e., mostly in its peripheral part-they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.

Original languageEnglish (US)
Pages (from-to)1243-1244
Number of pages2
JournalThe Lancet
Volume306
Issue number7947
DOIs
StatePublished - Dec 20 1975

ASJC Scopus subject areas

  • Medicine(all)

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