TY - JOUR
T1 - FUNCTIONAL SUBDIVISION OF ISLETS OF LANGERHANS AND POSSIBLE ROLE OF D CELLS
AU - Orci, Lelio
AU - Unger, Roger H
PY - 1975/12/20
Y1 - 1975/12/20
N2 - Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet-i.e., mostly in its peripheral part-they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.
AB - Immunocytochemical examination of the islets of Langerhans in various animal species, including man, indicates that insulin-producing cells (B cells), glucagon-producing cells (A cells), and cells producing somatostatin or a somatostatin-like peptide (D cells) are not randomly arranged within the islet. Whenever A cells are found in the islet-i.e., mostly in its peripheral part-they are accompanied by D cells. However, most B cells, which occupy a central position, are in contact only with other B cells. In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.
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U2 - 10.1016/S0140-6736(75)92078-4
DO - 10.1016/S0140-6736(75)92078-4
M3 - Article
C2 - 53729
AN - SCOPUS:0016754166
SN - 0140-6736
VL - 306
SP - 1243
EP - 1244
JO - The Lancet
JF - The Lancet
IS - 7947
ER -