Functionalizing low-density lipoprotein nanoparticles for In Vivo near-infrared optical imaging of cancer

Ian R. Corbin, Juan Chen, Hui Li, Weiguo Cao, Gang Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Low density lipoproteins (LDL) have long been recognized as a potential delivery system for exogenous agents. Imaging agents or drugs can be attached to LDL through surface loading, protein loading or core loading methods. The LDL delivery system has received considerable attention particularly among cancer biologists as it was observed that numerous cancers over-express the low density lipoprotein receptor (LDLR). In this paper we investigate the utility of LDL to transport optical imaging contrast agents for caner detection. The method of loading fluorophores into the core of LDL is attractive as it behaves like an activatable contrast agent. Surface and protein labeled methods also prove to be effective strategies for tracing LDL nanoparticle activity. The strengths and limitations of the LDL carrier system are discussed and novel approaches for imaging cancer with LDL nanoparticles are highlighted.

Original languageEnglish (US)
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2007
PublisherOptical Society of America
ISBN (Print)9780819467713
StatePublished - Jan 1 2007
EventEuropean Conference on Biomedical Optics, ECBO 2007 - Munich, Germany
Duration: Jun 17 2007Jun 17 2007

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2007
CountryGermany
CityMunich
Period6/17/076/17/07

Keywords

  • Caner
  • Folate receptor
  • In vivo
  • LDL receptor
  • Low density lipoprotein (LDL)
  • Nanoparticle
  • Near-infrared (NIR) imaging

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Corbin, I. R., Chen, J., Li, H., Cao, W., & Zheng, G. (2007). Functionalizing low-density lipoprotein nanoparticles for In Vivo near-infrared optical imaging of cancer. In European Conference on Biomedical Optics, ECBO 2007 (Optics InfoBase Conference Papers). Optical Society of America.