Abstract
Exposure to sunlight, particularly ultraviolet light (UV), can produce changes in the status of the immune system. Photoimmunology is the study of the distortions in "normal" immune responses that may be produced by UV and/or visible light exposure. Photoallergy, on the other hand, is an acquired im-munologically mediated reactivity to a chemical or drug precipitated by the formation of photoproducts. This article reviews the key principles with supporting evidence from both photoimmunology and photoallergy. Reviews of the fundamental concepts of cutaneous structure and function, inflammation, immunology, and allergic contact dermatitis are presented as introduction. Subsequent sections discuss the capacity of UV to alter allergic contact dermatitis. The second part of the article presents an overview of past clinical observations and important laboratory animal studies relevant to photoallergy, including new techniques for predictive testing for photoallergic contact dermatitis in animals and helpful suggestions for handling problems when assessing consumer products for photoallergenicity. The article concludes by presenting approaches to diagnosing patients with suspected photoallergic contact dermatitis and photosensitivity to chemicals and drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 193-218 |
| Number of pages | 26 |
| Journal | Cutaneous and Ocular Toxicology |
| Volume | 4 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
- Ophthalmology
Cite this
Fundamental concepts in photoimmunology and photoallergy. / Stephens, Thomas J.; Bergstresser, Paul R.
In: Cutaneous and Ocular Toxicology, Vol. 4, No. 3-4, 1985, p. 193-218.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fundamental concepts in photoimmunology and photoallergy
AU - Stephens, Thomas J.
AU - Bergstresser, Paul R.
PY - 1985
Y1 - 1985
N2 - Exposure to sunlight, particularly ultraviolet light (UV), can produce changes in the status of the immune system. Photoimmunology is the study of the distortions in "normal" immune responses that may be produced by UV and/or visible light exposure. Photoallergy, on the other hand, is an acquired im-munologically mediated reactivity to a chemical or drug precipitated by the formation of photoproducts. This article reviews the key principles with supporting evidence from both photoimmunology and photoallergy. Reviews of the fundamental concepts of cutaneous structure and function, inflammation, immunology, and allergic contact dermatitis are presented as introduction. Subsequent sections discuss the capacity of UV to alter allergic contact dermatitis. The second part of the article presents an overview of past clinical observations and important laboratory animal studies relevant to photoallergy, including new techniques for predictive testing for photoallergic contact dermatitis in animals and helpful suggestions for handling problems when assessing consumer products for photoallergenicity. The article concludes by presenting approaches to diagnosing patients with suspected photoallergic contact dermatitis and photosensitivity to chemicals and drugs.
AB - Exposure to sunlight, particularly ultraviolet light (UV), can produce changes in the status of the immune system. Photoimmunology is the study of the distortions in "normal" immune responses that may be produced by UV and/or visible light exposure. Photoallergy, on the other hand, is an acquired im-munologically mediated reactivity to a chemical or drug precipitated by the formation of photoproducts. This article reviews the key principles with supporting evidence from both photoimmunology and photoallergy. Reviews of the fundamental concepts of cutaneous structure and function, inflammation, immunology, and allergic contact dermatitis are presented as introduction. Subsequent sections discuss the capacity of UV to alter allergic contact dermatitis. The second part of the article presents an overview of past clinical observations and important laboratory animal studies relevant to photoallergy, including new techniques for predictive testing for photoallergic contact dermatitis in animals and helpful suggestions for handling problems when assessing consumer products for photoallergenicity. The article concludes by presenting approaches to diagnosing patients with suspected photoallergic contact dermatitis and photosensitivity to chemicals and drugs.
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U2 - 10.3109/15569528509033546
DO - 10.3109/15569528509033546
M3 - Article
AN - SCOPUS:0022387348
VL - 4
SP - 193
EP - 218
JO - Cutaneous and Ocular Toxicology
JF - Cutaneous and Ocular Toxicology
SN - 1556-9527
IS - 3-4
ER -